Title:
AMINO ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/002146
Kind Code:
A1
Abstract:
Compounds represented by general formula (I), salts thereof and type N calcium channel inhibitors containing the same as the active ingredient, wherein R?1¿ represents optionally substituted alkyl, alkoxy or phenyl, a heterocyclic group, etc.; A represents a single bond, CO or SO¿2?; R?2¿ represents H, optionally substituted alkyl, etc.; D represents alkylene, etc.; E represents COO, OCO, O, S, SO, SO¿2?, etc.; R?3¿ represents optionally substituted alkyl, a carbocyclic group or a heterocycle group; J represents O or NR?16¿ (wherein R?16¿ represents H or optionally substituted alkyl); and R?4¿ represents optionally substituted alkyl, a carbocyclic group or a heterocyclic group. Because of inhibiting the type N calcium channel, the compounds (I) are useful as preventives and/or remedies for cerebral infarction, transient cerebral ischemic attack, cerebrospinal disorders following heart operations, spinal vascular lesion, stress hypertension, neurosis, epilepsy, etc. or remdies for pains.
Inventors:
SEKO TAKUYA (JP)
KATO MASASHI (JP)
KATO MASASHI (JP)
Application Number:
PCT/JP1998/003013
Publication Date:
January 21, 1999
Filing Date:
July 03, 1998
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
SEKO TAKUYA (JP)
KATO MASASHI (JP)
SEKO TAKUYA (JP)
KATO MASASHI (JP)
International Classes:
C07C233/46; C07C233/47; C07C233/51; C07C233/83; C07C235/52; C07C235/84; C07C237/08; C07C237/22; C07C237/36; C07C271/22; C07C309/18; C07C311/06; C07C311/13; C07C311/14; C07C311/19; C07C311/29; C07C311/46; C07C317/50; C07C323/59; C07C323/60; C07C323/62; C07D207/16; C07D211/14; C07D211/20; C07D211/58; C07D211/62; C07D213/30; C07D213/32; C07D213/64; C07D213/643; C07D213/75; C07D213/81; C07D213/82; C07D215/06; C07D215/08; C07D215/12; C07D217/06; C07D233/54; C07D233/90; C07D263/34; C07D277/04; C07D277/06; C07D277/14; C07D277/16; C07D277/56; C07D279/06; C07D279/12; C07D295/135; C07D295/185; C07D307/14; C07D307/24; C07D307/42; C07D307/52; C07D307/68; C07D309/04; C07D309/06; C07D333/16; C07D333/20; C07D333/38; C07D417/12; C07K5/072; C07K5/078; A61K38/00; (IPC1-7): A61K31/165; A61K31/18; A61K31/215; A61K31/27; A61K31/34; A61K31/38; A61K31/42; A61K31/425; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/535; A61K31/54; A61K38/00; C07C227/20; C07C229/26; C07C233/47; C07C233/51; C07C233/83; C07C235/52; C07C235/84; C07C237/22; C07C237/36; C07C271/22; C07C277/04; C07C311/06; C07C311/19; C07C317/50; C07C323/59; C07C323/62; C07D211/62; C07D213/62; C07D213/81; C07D215/12; C07D217/06; C07D233/64; C07D233/90; C07D263/34; C07D277/56; C07D279/12; C07D295/12; C07D295/18; C07D295/22; C07D307/42; C07D307/52; C07D307/24; C07D333/20; C07D333/38; C07D417/12; C07K15/037
Domestic Patent References:
| WO1994007815A2 | 1994-04-14 |
Foreign References:
| EP0520200A2 | 1992-12-30 | |||
| JPH08208690A | 1996-08-13 | |||
| JPH0680696A | 1994-03-22 |
Other References:
SHONO T., ET AL.: "A NEW SYNTHETIC METHOD OF ALPHA-AMINO ACIDS FROM ALPHA-METHOXYURETHANES.", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 22., no. 25., 1 January 1981 (1981-01-01), GB, pages 2411/2412., XP002912983, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)82922-1
Attorney, Agent or Firm:
Ohie, Kunihisa (7F 2-6, Nihonbashi-Ningyocho 2-chome Chuo-ku Tokyo, JP)
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