Title:
AMINO ACID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/033787
Kind Code:
A1
Abstract:
Novel amino acid derivatives represented by the following general formula and salts thereof and chemokine receptor antagonists containing the same as the active ingredient: R?1¿-X?1¿-ph-X?2¿-A-Y-R?2¿, wherein A represents an amino acid residue selected from among Arg, Lys and Orn or a peptide consisting of 2 or 3 amino acid residues selected from among Arg, Lys, Orn, Leu, Ala, Val, Ile, Gly, Glu and Asp which contains at least one of Arg, Lys and Orn; R?1¿ and R?2¿ independently represent each alkyl, alkenyl, cholesteryl or hydrogen, provided that at least one of R?1¿ and R?2¿ represents C¿12-30? alkyl, alkenyl or cholesteryl; X?1¿ is absent or represents -(C=O)-, -(C=O)-NH-, -(C=O)-O-, -NH-(C=O)-, -NH-(C=O)-NH-, -(S=O)-, -SO¿2?-, -NH-, -O-, -S-, etc.; X?2¿ is absent or represents -(C=O)-, -(S=O)-, -SO¿2?-, -NH-(C=O)-, etc.; Y is absent or represents -O-, -S-, -NH- or -NR?3¿; and ph is absent or present at an arbitrary substitution site of o-, m- or p-.
Inventors:
MARUOKA HIROSHI (JP)
SUZUKI SHIGERU (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
HAKOZAKI MICHINORI (JP)
YAMAZAKI TORU (JP)
DEWA TOSHIKAZU (JP)
TAKEMURA YOSHIYUKI (JP)
INOGUCHI EIJI (JP)
EDAMATSU TAKEO (JP)
SUZUKI SHIGERU (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
HAKOZAKI MICHINORI (JP)
YAMAZAKI TORU (JP)
DEWA TOSHIKAZU (JP)
TAKEMURA YOSHIYUKI (JP)
INOGUCHI EIJI (JP)
EDAMATSU TAKEO (JP)
Application Number:
PCT/JP1998/005742
Publication Date:
July 08, 1999
Filing Date:
December 18, 1998
Export Citation:
Assignee:
KUREHA CHEMICAL IND CO LTD (JP)
MARUOKA HIROSHI (JP)
SUZUKI SHIGERU (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
HAKOZAKI MICHINORI (JP)
YAMAZAKI TORU (JP)
DEWA TOSHIKAZU (JP)
TAKEMURA YOSHIYUKI (JP)
INOGUCHI EIJI (JP)
EDAMATSU TAKEO (JP)
MARUOKA HIROSHI (JP)
SUZUKI SHIGERU (JP)
HIROSE KUNITAKA (JP)
YANAKA MIKIRO (JP)
HAKOZAKI MICHINORI (JP)
YAMAZAKI TORU (JP)
DEWA TOSHIKAZU (JP)
TAKEMURA YOSHIYUKI (JP)
INOGUCHI EIJI (JP)
EDAMATSU TAKEO (JP)
International Classes:
C07K5/06; C07K5/093; A61K38/00; (IPC1-7): C07C233/47; A61K38/05; A61K38/06; C07C237/22
Domestic Patent References:
| WO1997043308A1 | 1997-11-20 |
Foreign References:
| US5696231A | 1997-12-09 | |||
| JPS61130268A | 1986-06-18 | |||
| JPH09173067A | 1997-07-08 | |||
| JPH05271035A | 1993-10-19 | |||
| JPH0426662A | 1992-01-29 | |||
| JPS60214768A | 1985-10-28 |
Attorney, Agent or Firm:
Fujino, Seiya (Yotsuya 1-chome Shinjuku-ku Tokyo, JP)
Download PDF:
Previous Patent: METHOD FOR PRODUCING OXALKYLATED AMINES OR ALCOHOLS
Next Patent: METHOD FOR PRODUCING AROMATIC BROMOMETHYL BIPHENYL COMPOUNDS
Next Patent: METHOD FOR PRODUCING AROMATIC BROMOMETHYL BIPHENYL COMPOUNDS