AMINO THIOL COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY

WIPO Patent Application WO2005014524

A3

The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more chernoprotective polyamines or amino thiols formulated for topical or local delivery to epithelial or mucosal cells are disclosed. Methods of administering the pharmaceutical preparations are also disclosed.

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FAHL WILLIAM E (US)
PEEBLES DANIEL D (US)
COPP RICHARD R (US)

PCT/US2004/026535

July 07, 2005

August 09, 2004

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WISCONSIN ALUMNI RES FOUND (US)
FAHL WILLIAM E (US)
PEEBLES DANIEL D (US)
COPP RICHARD R (US)

C07C211/14; C07C211/22; C07C215/18; C07C215/24; C07C323/25; C07C323/27; (IPC1-7): C07C211/14; A61K31/132; A61K31/133; A61K31/145; C07C211/22; C07C215/18; C07C215/24; C07C323/25; C07C323/27

WO2003066572A1	2003-08-14
WO2003013245A1	2003-02-20
WO1994027961A1	1994-12-08
WO1994019311A1	1994-09-01

PIPER, JAMES R. ET AL: "S-2,.omega.-Diaminoalkyl dihydrogen phosphorothioates as antiradiation agents", JOURNAL OF MEDICINAL CHEMISTRY , CODEN: JMCMAR; ISSN: 0022-2623, vol. 22, no. 6, 1979, pages 631 - 639, XP002314914
J.W. PURDIE: "A comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells", RADIATION RESEARCH, vol. 77, 1979, pages 303 - 311, XP009043048

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