ANIMALS WITH INSUFFICIENT EXPRESSION OF URIDINE PHOSPHORYLASE

Title:

ANIMALS WITH INSUFFICIENT EXPRESSION OF URIDINE PHOSPHORYLASE

Document Type and Number:

WIPO Patent Application WO/2001/043539

Kind Code:

A1

Abstract:

Chromosomal uridine phosphorylase knockout non-human animals and offspring thereof. These animals make it possible to clarify the pathological physiology of nucleic acid metabolic errors, etc. and estimate the usefulness of pyrimidine nucleoside-type metabolic antagonists in humans, etc. Thus, they are useful as animals for experiments.

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Inventors:

NODA TETSUO (JP)
TSUJIMOTO HIROAKI (JP)
FUKUSHIMA MASAKAZU (JP)

Application Number:

PCT/JP2000/008898

Publication Date:

June 21, 2001

Filing Date:

December 15, 2000

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Assignee:

TAIHO PHARMACEUTICAL CO LTD (JP)
NODA TETSUO (JP)
TSUJIMOTO HIROAKI (JP)
FUKUSHIMA MASAKAZU (JP)

International Classes:

A01K67/027; C12N5/10; C12N15/09; C12N9/10; C12N15/85; (IPC1-7): A01K67/027

Other References:

WATANABE S. ET AL.: "Purification, Cloning and Expression of Murine Udine Phosphorylase", J. BIOL. CHEM., vol. 270, no. 20, 1995, pages 12191 - 12196, XP002937368
CAPECCHI M.R. ET AL.: "Altering the Genome by Homologous Recombination", SCIENCE, vol. 244, 1989, pages 1288 - 1292, XP002937369
KENICHI YAMAMURA, IDENSHI IRYOU, vol. 2, no. 4, 1998, pages 104(612) - 109(617), XP002937370
See also references of EP 1153543A4

Attorney, Agent or Firm:

Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku Tokyo, JP)

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