Title:
ANTI-CD137 ANTIBODY AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/078149
Kind Code:
A1
Abstract:
Provided is an antibody capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. Also provided are the uses of the antibody or antigen binding fragment thereof in preparing a drug.
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Inventors:
ZHANG XIN (CN)
PENG JIANJIAN (CN)
FU KAI (CN)
MA HUI (CN)
PAN XIAOLONG (CN)
FU SHILONG (CN)
MA SHULI (CN)
DING JIAN (CN)
PENG JIANJIAN (CN)
FU KAI (CN)
MA HUI (CN)
PAN XIAOLONG (CN)
FU SHILONG (CN)
MA SHULI (CN)
DING JIAN (CN)
Application Number:
PCT/CN2019/105537
Publication Date:
April 23, 2020
Filing Date:
September 12, 2019
Export Citation:
Assignee:
DINGFU BIOTARGET CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/12
Domestic Patent References:
| WO2017049452A1 | 2017-03-30 | |||
| WO2018127787A1 | 2018-07-12 | |||
| WO2018011421A1 | 2018-01-18 |
Foreign References:
| CN1566341A | 2005-01-19 |
Other References:
SHEN BEIFEN: "Antibodies for Tumor Therapy and their Modification Strategy", CHINESE JOURNAL OF CANCER BIOTHERAPY, vol. 14, no. 2, 15 April 2007 (2007-04-15), CN, pages 101 - 104, XP055813255, ISSN: 1007-385X
JAAFAR N. HAIDAR, QING-AN YUAN, LIN ZENG, MARK SNAVELY, XENIA LUNA, HAIFAN ZHANG, WEI ZHU, DALE L. LUDWIG, ZHENPING ZHU: "A universal combinatorial design of antibody framework to graft distinct CDR sequences: A bioinformatics approach", PROTEIN, vol. 80, no. 3, 11 November 2011 (2011-11-11), pages 896 - 912, XP055703859, ISSN: 0887-3585, DOI: 10.1002/prot.23246
POLLOK, KE ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 367 - 374
KWON, B.S. ET AL., PNAS, vol. 86, 1989, pages 1963 - 67
WUKABAT, J EXP MED, vol. 132, 1970, pages 211 - 50
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
LAZIKANI ET AL., J MOL BIOL, vol. 273, 1997, pages 927 - 48
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 5879 - 5883
SILVA, JOHN-PAUL ET AL.: "The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation", JOURNAL OF BIOLOGICAL CHEMISTRY
PLEASEEDELMAN ET AL., PROC NATL ACAD SCI USA, vol. 63, 1969, pages 78 - 85
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBE ET AL.: "Current Protocols in Molecular Biology", 1993, GREENE PUBLISHING AND WILEY-INTERSCIENCE
See also references of EP 3885364A4
JAAFAR N. HAIDAR, QING-AN YUAN, LIN ZENG, MARK SNAVELY, XENIA LUNA, HAIFAN ZHANG, WEI ZHU, DALE L. LUDWIG, ZHENPING ZHU: "A universal combinatorial design of antibody framework to graft distinct CDR sequences: A bioinformatics approach", PROTEIN, vol. 80, no. 3, 11 November 2011 (2011-11-11), pages 896 - 912, XP055703859, ISSN: 0887-3585, DOI: 10.1002/prot.23246
POLLOK, KE ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 367 - 374
KWON, B.S. ET AL., PNAS, vol. 86, 1989, pages 1963 - 67
WUKABAT, J EXP MED, vol. 132, 1970, pages 211 - 50
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, UNITED STATES PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
LAZIKANI ET AL., J MOL BIOL, vol. 273, 1997, pages 927 - 48
WARD ET AL., NATURE, vol. 341, 1989, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 5879 - 5883
SILVA, JOHN-PAUL ET AL.: "The S228P mutation prevents in vivo and in vitro IgG4 Fab-arm exchange as demonstrated using a combination of novel quantitative immunoassays and physiological matrix preparation", JOURNAL OF BIOLOGICAL CHEMISTRY
PLEASEEDELMAN ET AL., PROC NATL ACAD SCI USA, vol. 63, 1969, pages 78 - 85
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
AUSUBE ET AL.: "Current Protocols in Molecular Biology", 1993, GREENE PUBLISHING AND WILEY-INTERSCIENCE
See also references of EP 3885364A4
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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