Title:
ANTI-HUMAN P40 PROTEIN DOMAIN ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/018114
Kind Code:
A1
Abstract:
Provided is an antibody for the treatment or prevention of autoimmune diseases, comprising a heavy chain variable region represented by SEQ ID NO: 1 or SEQ ID NO: 24, and a light chain variable region represented by SEQ ID NO: 6, SEQ ID NO: 11, SEQ ID NO: 13, SEQ ID NO: 15, SEQ ID NO: 17, or SEQ ID NO: 25.
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Inventors:
XIA YU (CN)
WANG ZHONGMIN MAXWELL (CN)
ZHANG PENG (CN)
LI BAIYONG (CN)
WANG ZHONGMIN MAXWELL (CN)
ZHANG PENG (CN)
LI BAIYONG (CN)
Application Number:
PCT/CN2020/105039
Publication Date:
February 04, 2021
Filing Date:
July 28, 2020
Export Citation:
Assignee:
AKESO BIOPHARMA INC (CN)
International Classes:
C07K16/24; A61K39/395; A61P1/04; A61P37/00; C07K16/46; C07K19/00; C12N15/13; C12N15/62; C12N15/63; G01N33/50
Domestic Patent References:
| WO1988001649A1 | 1988-03-10 |
Foreign References:
| CN103275222A | 2013-09-04 | |||
| CN109400709A | 2019-03-01 | |||
| CN102177178A | 2011-09-07 | |||
| CN101379085A | 2009-03-04 | |||
| CN201910706137A | 2019-07-30 | |||
| US4946778A | 1990-08-07 | |||
| US5260203A | 1993-11-09 | |||
| US4816567A | 1989-03-28 | |||
| CN103275222A | 2013-09-04 |
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ROSMARIN D ET AL., JOURNAL OF DRUGS IN DERMATOLOGY, vol. 4, no. 3, 2005, pages 318 - 325
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KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
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PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31
GONNET ET AL., SCIENCE, vol. 256, 1992, pages 1443 - 45
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63 - 98
PEARSON, METHODS MOL. BIOL., vol. 132, 2000, pages 185 - 219
ALTSCHUL ET AL., MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 402
DULL TZUFFEREY RKELLY MMANDEL RJNGUYEN MTRONO DNALDINI L.: "A Third Generation Lentivirus Vector with a Conditional Packaging System", J VIROL., vol. 72, no. 11, 1998, pages 8463 - 8471, XP055715204, DOI: 10.1128/JVI.72.11.8463-8471.1998
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JELTSCH-DAVID H., AUTOIMMUN REV., vol. 13, no. 9, 2014, pages 963 - 973
See also references of EP 4008727A4
MANETTI R ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, vol. 177, no. 4, 1993, pages 1199 - 1204
ROSMARIN D ET AL., JOURNAL OF DRUGS IN DERMATOLOGY, vol. 4, no. 3, 2005, pages 318 - 325
MARTIN ACRCHEETHAM JCREES AR: "Modelling antibody hypervariableloops: A combined algorithm", PROC NATL ACAD SCI USA, vol. 86, 1989, pages 9268 - 9272
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 341, 1989, pages 544 - 546
LEFRANC ET AL., DEV. COMPARAT. IMMUNOL., vol. 27, 2003, pages 55 - 77
"GenBank", Database accession no. 149233
LIU JIANJUN, CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 4, 1989, pages 29 - 29
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1988, pages 5879 - 5883
SONGSIVILAILACHMANN, CLIN. EXP. IMMUNOL., vol. 79, 1990, pages 315 - 321
KOSTELNY ET AL., J. IMMUNOL., vol. 148, 1992, pages 1547 - 1553
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK, IMMUNOL. TODAY, vol. 21, 2000, pages 397 - 402
"Epitope Mapping Protocols in Methods in Molecular Biology", vol. 66, 1996
PEARSON, METHODS MOL. BIOL., vol. 243, 1994, pages 307 - 31
GONNET ET AL., SCIENCE, vol. 256, 1992, pages 1443 - 45
PEARSON, METHODS ENZYMOL., vol. 183, 1990, pages 63 - 98
PEARSON, METHODS MOL. BIOL., vol. 132, 2000, pages 185 - 219
ALTSCHUL ET AL., MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 402
DULL TZUFFEREY RKELLY MMANDEL RJNGUYEN MTRONO DNALDINI L.: "A Third Generation Lentivirus Vector with a Conditional Packaging System", J VIROL., vol. 72, no. 11, 1998, pages 8463 - 8471, XP055715204, DOI: 10.1128/JVI.72.11.8463-8471.1998
ACIERNO ET AL., J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 46
"GeneBank", Database accession no. 51561
JELTSCH-DAVID H., AUTOIMMUN REV., vol. 13, no. 9, 2014, pages 963 - 973
See also references of EP 4008727A4
Attorney, Agent or Firm:
BEIJING C&S LAW FIRM (CN)
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