Title:
ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/187706
Kind Code:
A3
Abstract:
Provided herein are antibodies that bind to neuraminidase (NA) of different strains of influenza B virus, host cells for producing such antibodies, and kits comprising such antibodies. Also provided herein are compositions comprising antibodies that bind to NA of different strains of influenza B virus and methods of using such antibodies to diagnose, prevent or treat influenza virus disease.
Inventors:
PALESE PETER (US)
KRAMMER FLORIAN (US)
WOHLBOLD TEDDY (US)
GARCIA-SASTRE ADOLFO (US)
KRAMMER FLORIAN (US)
WOHLBOLD TEDDY (US)
GARCIA-SASTRE ADOLFO (US)
Application Number:
PCT/US2018/026489
Publication Date:
March 26, 2020
Filing Date:
April 06, 2018
Export Citation:
Assignee:
ICAHN SCHOOL MED MOUNT SINAI (US)
International Classes:
A61K39/145; C07K14/435; C07K16/10; C12N15/09; C12P19/34
Domestic Patent References:
| WO2016118937A1 | 2016-07-28 | |||
| WO2017021893A1 | 2017-02-09 | |||
| WO2005000901A2 | 2005-01-06 |
Foreign References:
| CN103665155A | 2014-03-26 | |||
| US20080193455A1 | 2008-08-14 | |||
| US20150266951A1 | 2015-09-24 | |||
| US20040073011A1 | 2004-04-15 | |||
| US20160017025A1 | 2016-01-21 | |||
| US20150252103A1 | 2015-09-10 | |||
| US20130224187A1 | 2013-08-29 | |||
| US20090169547A1 | 2009-07-02 | |||
| US20160185860A1 | 2016-06-30 | |||
| US20160355590A1 | 2016-12-08 | |||
| US20160015828A1 | 2016-01-21 |
Other References:
DOYLE, TM ET AL.: "A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 441, 16 October 2013 (2013-10-16), pages 226 - 229, XP028766146, DOI: 10.1016/j.bbrc.2013.10.041
GRAVEL, C ET AL.: "Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequences", VACCINE, vol. 28, 9 July 2010 (2010-07-09), pages 5774 - 5784, XP027204848
WOHLBOLD, TJ ET AL.: "Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice", CROSS-PROTECTION AGAINST INFLUENZA VIRUS INFECTION IN MICE . MBIO, vol. 6, no. 2, 10 March 2015 (2015-03-10), pages 1 - 13, XP055293875
HU , W ET AL.: "Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient", VIROLOGY, vol. 435, 16 October 2012 (2012-10-16), pages 320 - 328, XP055100211, DOI: 10.1016/j.virol.2012.09.034
AIR, GM: "Influenza virus antigenicity and broadly neutralizing epitopes", CURRENT OPINION IN VIROLOGY, vol. 11, 4 April 2015 (2015-04-04), pages 113 - 121, XP055695321
WOHLBOLD, TJ ET AL.: "Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes", NATURE MICROBIOLOGY, vol. 2, 21 August 2017 (2017-08-21), pages 1415 - 1424, XP036429518, DOI: 10.1038/s41564-017-0011-8
GRAVEL, C ET AL.: "Qualitative and quantitative analyses of virtually all subtypes of influenza A and B viral neuraminidases using antibodies targeting the universally conserved sequences", VACCINE, vol. 28, 9 July 2010 (2010-07-09), pages 5774 - 5784, XP027204848
WOHLBOLD, TJ ET AL.: "Vaccination with Adjuvanted Recombinant Neuraminidase Induces Broad Heterologous, but Not Heterosubtypic, Cross-Protection against Influenza Virus Infection in Mice", CROSS-PROTECTION AGAINST INFLUENZA VIRUS INFECTION IN MICE . MBIO, vol. 6, no. 2, 10 March 2015 (2015-03-10), pages 1 - 13, XP055293875
HU , W ET AL.: "Fully human broadly neutralizing monoclonal antibodies against influenza A viruses generated from the memory B cells of a 2009 pandemic H1N1 influenza vaccine recipient", VIROLOGY, vol. 435, 16 October 2012 (2012-10-16), pages 320 - 328, XP055100211, DOI: 10.1016/j.virol.2012.09.034
AIR, GM: "Influenza virus antigenicity and broadly neutralizing epitopes", CURRENT OPINION IN VIROLOGY, vol. 11, 4 April 2015 (2015-04-04), pages 113 - 121, XP055695321
WOHLBOLD, TJ ET AL.: "Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes", NATURE MICROBIOLOGY, vol. 2, 21 August 2017 (2017-08-21), pages 1415 - 1424, XP036429518, DOI: 10.1038/s41564-017-0011-8
Attorney, Agent or Firm:
CHHEDA, Jennifer, J. et al. (US)
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