Title:
ANTI-PD-L1 AND PD-L2 ANTIBODY AND DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/197358
Kind Code:
A1
Abstract:
Provided are a PD-L1 nano-antibody and a PD-L2 nano-antibody, and a bispecific antibody having both the PD-L1 nano-antibody and the PD-L2 nano-antibody. The bispecific antibody can block PD-1/PD-L1 and PD-1/PD-L2 pathways at the same time. The bispecific antibody in the present invention can reactivate T cells, enhance immune responses, and more effectively improve the inhibitory effect on tumor occurrence and development.
Inventors:
MIAO XIAONIU (CN)
WU FAN (CN)
CHEN CHENG (CN)
WU FAN (CN)
CHEN CHENG (CN)
Application Number:
PCT/CN2021/084196
Publication Date:
October 07, 2021
Filing Date:
March 30, 2021
Export Citation:
Assignee:
BIOTHEUS INC (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N15/13
Domestic Patent References:
| WO2019149219A1 | 2019-08-08 |
Foreign References:
| CN110256564A | 2019-09-20 | |||
| CN107686520A | 2018-02-13 | |||
| CN110003333A | 2019-07-12 | |||
| CN110627906A | 2019-12-31 | |||
| CN109096396A | 2018-12-28 | |||
| CN110372793A | 2019-10-25 | |||
| CN107636013A | 2018-01-26 |
Other References:
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
ESTEP, P ET AL.: "High throughput solution-based measurement of antibody-antigen affinity and epitope binning", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
VINCKE, C ET AL.: "General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold", J BIOL CHEM, vol. 284, no. 5, pages 3273 - 3284, XP055107615, DOI: 10.1074/jbc.M806889200
See also references of EP 4130041A4
ESTEP, P ET AL.: "High throughput solution-based measurement of antibody-antigen affinity and epitope binning", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
VINCKE, C ET AL.: "General strategy to humanize a camelid single-domain antibody and identification of a universal humanized nanobody scaffold", J BIOL CHEM, vol. 284, no. 5, pages 3273 - 3284, XP055107615, DOI: 10.1074/jbc.M806889200
See also references of EP 4130041A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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