Title:
ANTIBACTERIAL AGENT
Document Type and Number:
WIPO Patent Application WO/2016/021695
Kind Code:
A1
Abstract:
An antibacterial agent which is composed of a compound represented by general formula (I) or (II) or a salt thereof.
In formula (I), R1 represents a hydrogen atom, an alkyl group having 1-10 carbon atoms, or a phenyl group; R2 represents a hydrogen atom or an alkyl group having 1-10 carbon atoms; and X1 represents a hydrogen atom or a halogen atom.
In formula (II), R1 represents a hydrogen atom, an alkyl group having 2-10 carbon atoms, or a phenyl group; R2 represents a hydrogen atom or an alkyl group having 1-10 carbon atoms; and each of X1 and X2 independently represents a hydrogen atom or a halogen atom.
Inventors:
KUBOHARA YUZURU (JP)
OSHIMA YOSHITERU (JP)
KIKUCHI HARUHISA (JP)
OSHIMA YOSHITERU (JP)
KIKUCHI HARUHISA (JP)
Application Number:
PCT/JP2015/072400
Publication Date:
February 11, 2016
Filing Date:
August 06, 2015
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
A61K31/12; A01N35/04; A01P3/00; A61P31/04
Domestic Patent References:
| WO2001021164A2 | 2001-03-29 |
Other References:
PELTTARI, EILA ET AL.: "Antimicrobial properties of substituted salicylaldehydes and related compounds", Z. NATURFORSCH., vol. 62c, 2007, pages 487 - 497
REHN, D. ET AL.: "Zur antimiKrobiellen wirksamkeit substituierter aromatischer aldehyde(About the antimicrobial activity of substituted aromatic aldehydes", ZBL. BAKT. HYG., I. ABT. ORIG. B, vol. 172, 1981, pages 508 - 19
PELTTARI, EILA ET AL.: "Substituted salicylaldehydes as potential antimicrobial drugs: minimal inhibitory and microbicidal concentrations", Z. NATURFORSCH., vol. 66c, 2011, pages 571 - 580
BONIFAIT, LAETITIA ET AL.: "Synthesis and antimicrobial activity of geranyloxy- and farnesyloxy-acetophenone derivatives against oral pathogens", FITOTERAPIA, vol. 83, no. 6, pages 996 - 999, XP028427379, DOI: doi:10.1016/j.fitote.2012.06.003
RAMOS-NINO, M. E. ET AL.: "QSARs for the effect of benzaldehydes on foodborne bacteria and the role of sulfhydryl groups as targets of their antibacterial activity", J. APPL MICROBIOL., vol. 84, 1998, pages 207 - 212, XP003017735, DOI: doi:10.1046/j.1365-2672.1998.00324.x
NGAN, LUONG THI MY ET AL.: "Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori", J. AGRIC. FOOD CHEM, vol. 60, 31 August 2012 (2012-08-31), pages 9062 - 9073
FRIEDMAN, MENDEL ET AL.: "Antibacterial activities of phenolic benzaldehydes and benzoic acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica", J. FOOD PROT., vol. 66, no. 10, 2003, pages 1811 - 1821, XP008123125
REHN, D. ET AL.: "Zur antimiKrobiellen wirksamkeit substituierter aromatischer aldehyde(About the antimicrobial activity of substituted aromatic aldehydes", ZBL. BAKT. HYG., I. ABT. ORIG. B, vol. 172, 1981, pages 508 - 19
PELTTARI, EILA ET AL.: "Substituted salicylaldehydes as potential antimicrobial drugs: minimal inhibitory and microbicidal concentrations", Z. NATURFORSCH., vol. 66c, 2011, pages 571 - 580
BONIFAIT, LAETITIA ET AL.: "Synthesis and antimicrobial activity of geranyloxy- and farnesyloxy-acetophenone derivatives against oral pathogens", FITOTERAPIA, vol. 83, no. 6, pages 996 - 999, XP028427379, DOI: doi:10.1016/j.fitote.2012.06.003
RAMOS-NINO, M. E. ET AL.: "QSARs for the effect of benzaldehydes on foodborne bacteria and the role of sulfhydryl groups as targets of their antibacterial activity", J. APPL MICROBIOL., vol. 84, 1998, pages 207 - 212, XP003017735, DOI: doi:10.1046/j.1365-2672.1998.00324.x
NGAN, LUONG THI MY ET AL.: "Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori", J. AGRIC. FOOD CHEM, vol. 60, 31 August 2012 (2012-08-31), pages 9062 - 9073
FRIEDMAN, MENDEL ET AL.: "Antibacterial activities of phenolic benzaldehydes and benzoic acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica", J. FOOD PROT., vol. 66, no. 10, 2003, pages 1811 - 1821, XP008123125
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
Yoshiyuki Kawaguchi (JP)
Yoshiyuki Kawaguchi (JP)
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