Title:
ANTIBODIES AGAINST DISEASE CAUSING AGENTS OF POULTRY AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/035741
Kind Code:
A3
Abstract:
Described herein are methods and antibodies useful for reducing, eliminating, or preventing infection with a bacterial population in an animal. Also described herein are antigens useful for targeting by heavy chain antibodies and VHH fragments for reducing a bacterial population in an animal.
Inventors:
ABNOUSI HAMLET (CA)
LOUTET SLADE (CA)
VAN PETEGEM FILIP LOUIS ARSENE (CA)
CHEUNG TSZ YING SYLVIA (CA)
LOUTET SLADE (CA)
VAN PETEGEM FILIP LOUIS ARSENE (CA)
CHEUNG TSZ YING SYLVIA (CA)
Application Number:
PCT/IB2019/001198
Publication Date:
May 07, 2020
Filing Date:
July 03, 2019
Export Citation:
Assignee:
NOVOBIND LIVESTOCK THERAPEUTICS INC (CA)
International Classes:
C07K16/12; A61K39/40; A61P31/04; C07K16/00; C07K16/40; C12N15/13; C12N15/63; C12P21/08
Other References:
FERNANDES DA COSTA, S.P. ET AL.: "Variable protection against experimental broiler necrotic enteritis after immunization with the C-terminal fragment of Clostridium perfringens alpha-toxin and a non-toxic NetB variant", AVIAN PATHOLOGY, vol. 45, no. 3, June 2016 (2016-06-01), pages 381 - 388, XP055706652
MCCLAIN, M.S. ET AL.: "Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin", INFECTION AND IMMUNITY, vol. 75, no. 4, 29 January 2007 (2007-01-29), pages 1785 - 1793, XP055425475, DOI: 10.1128/IAI.01643-06
SATO, H. ET AL.: "Monoclonal antibodies against alpha toxin", FEMS MICROBIOLOGY LETTERS, vol. 50, no. 1-2, May 1989 (1989-05-01), pages 173 - 176, XP025421042, DOI: 10.1111/j.1574-6968.1989.tb03104.x
ZENG, J. ET AL.: "The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin", JOURNAL OF IMMUNOLOGICAL RESEARCH, vol. 2016, 9 August 2016 (2016-08-09), pages 1 - 16, XP055706659
KEYBURN, A.L. ET AL.: "Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis", VETERINARY RESEARCH, vol. 44, no. 54, 16 July 2013 (2013-07-16), pages 1 - 8, XP021156068
ARBABI-GHAHROUDI, M.: "Camelid Single-domain antibodies: historical perspective and future outlook", FRONTIERS IN IMMUNOLOGY, vol. 8, no. 1589, November 2017 (2017-11-01), pages 1 - 8, XP055706663
MCCLAIN, M.S. ET AL.: "Functional analysis of neutralizing antibodies against Clostridium perfringens epsilon-toxin", INFECTION AND IMMUNITY, vol. 75, no. 4, 29 January 2007 (2007-01-29), pages 1785 - 1793, XP055425475, DOI: 10.1128/IAI.01643-06
SATO, H. ET AL.: "Monoclonal antibodies against alpha toxin", FEMS MICROBIOLOGY LETTERS, vol. 50, no. 1-2, May 1989 (1989-05-01), pages 173 - 176, XP025421042, DOI: 10.1111/j.1574-6968.1989.tb03104.x
ZENG, J. ET AL.: "The Generation and Characterization of Recombinant Protein and Antibodies of Clostridium perfringens Beta2 Toxin", JOURNAL OF IMMUNOLOGICAL RESEARCH, vol. 2016, 9 August 2016 (2016-08-09), pages 1 - 16, XP055706659
KEYBURN, A.L. ET AL.: "Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis", VETERINARY RESEARCH, vol. 44, no. 54, 16 July 2013 (2013-07-16), pages 1 - 8, XP021156068
ARBABI-GHAHROUDI, M.: "Camelid Single-domain antibodies: historical perspective and future outlook", FRONTIERS IN IMMUNOLOGY, vol. 8, no. 1589, November 2017 (2017-11-01), pages 1 - 8, XP055706663
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