Title:
ANTIBODY ("11C7") ANTI NOGO A AND ITS PHARMACEUTICAL USE
Document Type and Number:
WIPO Patent Application WO2004052932
Kind Code:
A3
Abstract:
This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant < 1000nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair; a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair.
Inventors:
BARSKE CARMEN (DE)
MIR ANIS KHUSRO (FR)
OERTLE THOMAS (CH)
SCHNELL LISA (CH)
SCHWAB MARTIN E (CH)
VITALITI ALESSANDRA (CH)
ZURINI MAURO (CH)
MIR ANIS KHUSRO (FR)
OERTLE THOMAS (CH)
SCHNELL LISA (CH)
SCHWAB MARTIN E (CH)
VITALITI ALESSANDRA (CH)
ZURINI MAURO (CH)
Application Number:
PCT/EP2003/013960
Publication Date:
October 21, 2004
Filing Date:
December 09, 2003
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
UNIV ZUERICH (CH)
BARSKE CARMEN (DE)
MIR ANIS KHUSRO (FR)
OERTLE THOMAS (CH)
SCHNELL LISA (CH)
SCHWAB MARTIN E (CH)
VITALITI ALESSANDRA (CH)
ZURINI MAURO (CH)
NOVARTIS PHARMA GMBH (AT)
UNIV ZUERICH (CH)
BARSKE CARMEN (DE)
MIR ANIS KHUSRO (FR)
OERTLE THOMAS (CH)
SCHNELL LISA (CH)
SCHWAB MARTIN E (CH)
VITALITI ALESSANDRA (CH)
ZURINI MAURO (CH)
International Classes:
C07K14/47; C07K16/18; C12N15/13; (IPC1-7): C07K16/18; C12N15/13; C12N15/85; C12N5/10; A61K39/395
Domestic Patent References:
| WO2001051520A2 | 2001-07-19 | |||
| WO2002088306A2 | 2002-11-07 | |||
| WO2003048083A2 | 2003-06-12 |
Foreign References:
| EP1174441A2 | 2002-01-23 |
Other References:
MERKLER DORON ET AL: "Locomotor recovery in spinal cord-injured rats treated with an antibody neutralizing the myelin-associated neurite growth inhibitor Nogo-A", JOURNAL OF NEUROSCIENCE, vol. 21, no. 10, 15 May 2001 (2001-05-15), pages 3665 - 3673, XP002293416, ISSN: 0270-6474
POT CAROLINE ET AL: "Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury", JOURNAL OF CELL BIOLOGY, vol. 159, no. 1, 14 October 2002 (2002-10-14), pages 29 - 35, XP002293417, ISSN: 0021-9525
RAINETEAU O ET AL: "Improved locomotor recovery in spinal cord injured rats treated with the monoclonal antibody IN-1", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 1833, XP001199820, ISSN: 0190-5295
LI W ET AL: "NEUTRALIZATION OF MYELIN - ASSOCIATED NOGO - A BY A NOGO RECEPTOR - Fc FUSION PROTEIN.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 333.2 URL - http://sf, XP001199824
CHOI E D ET AL: "CHARACTERIZATION OF AN ANTI - NOGO RECEPTOR FAB THAT DISRUPTS NOGOA/NOGO RECEPTOR INTERACTION.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 333.1 URL - http://sf, XP001199822
PAPADOPOULOS CATHERINE M ET AL: "Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat", ANNALS OF NEUROLOGY, vol. 51, no. 4, April 2002 (2002-04-01), pages 433 - 441, XP008034394, ISSN: 0364-5134
PRINJHA R ET AL: "Characterisation and CNS localisation of Nogo and the Nogo-loop66 receptor", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 670, XP001199821, ISSN: 0190-5295
POT CAROLINE ET AL: "Nogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury", JOURNAL OF CELL BIOLOGY, vol. 159, no. 1, 14 October 2002 (2002-10-14), pages 29 - 35, XP002293417, ISSN: 0021-9525
RAINETEAU O ET AL: "Improved locomotor recovery in spinal cord injured rats treated with the monoclonal antibody IN-1", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 2, 2001, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 1833, XP001199820, ISSN: 0190-5295
LI W ET AL: "NEUTRALIZATION OF MYELIN - ASSOCIATED NOGO - A BY A NOGO RECEPTOR - Fc FUSION PROTEIN.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 333.2 URL - http://sf, XP001199824
CHOI E D ET AL: "CHARACTERIZATION OF AN ANTI - NOGO RECEPTOR FAB THAT DISRUPTS NOGOA/NOGO RECEPTOR INTERACTION.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 333.1 URL - http://sf, XP001199822
PAPADOPOULOS CATHERINE M ET AL: "Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat", ANNALS OF NEUROLOGY, vol. 51, no. 4, April 2002 (2002-04-01), pages 433 - 441, XP008034394, ISSN: 0364-5134
PRINJHA R ET AL: "Characterisation and CNS localisation of Nogo and the Nogo-loop66 receptor", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, & 31ST ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; SAN DIEGO, CALIFORNIA, USA; NOVEMBER 10-15, 2001, pages 670, XP001199821, ISSN: 0190-5295
Download PDF:
Previous Patent: NEGATIVELY CHARGED ANTIVIRAL PROTEIN CONJUGATES
Next Patent: PEPTIDE OLIGOMERS FOR USE AS HIV VACCINES
Next Patent: PEPTIDE OLIGOMERS FOR USE AS HIV VACCINES