Title:
ANTIGEN-SPECIFIC IGE ANTIBODY PRODUCTION INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2001/051079
Kind Code:
A1
Abstract:
Mammalian (including human) IgE antibody production inhibitors and immunomodulatory compositions containing as the active ingredient lactoferrin (LF) or its hydrolyzate; and IFN-$g(g) production potentiators containing LF or its hydrolyzate and ceramides.
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Inventors:
TAKAHASHI TAKESHI (JP)
NAGABUCHI SHINYA (JP)
NAKAMURA YOSHITAKA (JP)
YAJIMA TAKAJI (JP)
KUWATA TAMOTSU (JP)
NAGABUCHI SHINYA (JP)
NAKAMURA YOSHITAKA (JP)
YAJIMA TAKAJI (JP)
KUWATA TAMOTSU (JP)
Application Number:
PCT/JP2001/000161
Publication Date:
July 19, 2001
Filing Date:
January 12, 2001
Export Citation:
Assignee:
MEIJI MILK PROD CO LTD (JP)
TAKAHASHI TAKESHI (JP)
NAGABUCHI SHINYA (JP)
NAKAMURA YOSHITAKA (JP)
YAJIMA TAKAJI (JP)
KUWATA TAMOTSU (JP)
TAKAHASHI TAKESHI (JP)
NAGABUCHI SHINYA (JP)
NAKAMURA YOSHITAKA (JP)
YAJIMA TAKAJI (JP)
KUWATA TAMOTSU (JP)
International Classes:
A61K31/661; A61K31/706; A61K38/01; A61K38/40; A61P31/04; A61P31/12; A61P35/00; A61P37/04; A61P43/00; (IPC1-7): A61K38/40; A61K31/661; A61K31/706; A61P31/04; A61P31/12; A61P35/00; A61P37/04; A61P43/00
Domestic Patent References:
| WO1997026891A1 | 1997-07-31 | |||
| WO1999041266A1 | 1999-08-19 |
Foreign References:
| US5958891A | 1999-09-28 | |||
| JPH09194388A | 1997-07-29 | |||
| JPH1045618A | 1998-02-17 | |||
| EP0327461A1 | 1989-08-09 | |||
| US5936076A | 1999-08-10 | |||
| EP0729750A1 | 1996-09-04 |
Other References:
NAKAJIMA MITSUNARI ET AL.: "Oral administration of lactoferrin enhances the productions of IFN-gamma and IL-10 in spleen cells cultured with concanavalin A or lipopolysaccharide", BIOMED. RES., vol. 20, no. 1, 1999, pages 27 - 33, XP002938927
YOSHIMOTO TOMOHIRO ET AL.: "Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells", PROC. NATL. ACAD. SCI. USA, vol. 94, no. 8, 1997, pages 3948 - 3953, XP002938928
YOSHIMOTO TOMOHIRO ET AL.: "LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2Rbeta+ T cells", J. IMMUNOL., vol. 161, no. 3, 1998, pages 1483 - 1492, XP002938929
PRIESCHL EVA E. ET AL.: "The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc.epsilon. receptor I triggering", J. EXP. MED., vol. 190, no. 1, 1999, pages 1 - 8, XP002938930
BURDIN N. ET AL.: "Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 29, no. 6, 1999, pages 2014 - 2025, XP002938932
DEBBABI HAJER: "Bovine lactoferrin induces both mucosal and systemic immune response in mice", J. DAIRY RES., vol. 65, no. 2, 1998, pages 283 - 293, XP002938931
YOSHIMOTO TOMOHIRO ET AL.: "Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells", PROC. NATL. ACAD. SCI. USA, vol. 94, no. 8, 1997, pages 3948 - 3953, XP002938928
YOSHIMOTO TOMOHIRO ET AL.: "LPS-stimulated SJL macrophages produce IL-12 and IL-18 that inhibit IgE production in vitro by induction of IFN-gamma production from CD3intIL-2Rbeta+ T cells", J. IMMUNOL., vol. 161, no. 3, 1998, pages 1483 - 1492, XP002938929
PRIESCHL EVA E. ET AL.: "The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc.epsilon. receptor I triggering", J. EXP. MED., vol. 190, no. 1, 1999, pages 1 - 8, XP002938930
BURDIN N. ET AL.: "Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 29, no. 6, 1999, pages 2014 - 2025, XP002938932
DEBBABI HAJER: "Bovine lactoferrin induces both mucosal and systemic immune response in mice", J. DAIRY RES., vol. 65, no. 2, 1998, pages 283 - 293, XP002938931
Attorney, Agent or Firm:
Aruga, Mitsuyuki (Nihonbashiningyocho 1-chome Chuo-ku, Tokyo, JP)
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