Title:
APOPTOSIS INDUCER
Document Type and Number:
WIPO Patent Application WO/2015/194522
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a composition for effectively inducing apoptosis and/or proliferation inhibition in cells; and a method in which the composition is used.
The present invention relates to: an agent for inducing apoptosis, which contains a GST-π-inhibiting drug and a RB1CC1-inhibiting drug as active ingredients; a pharmaceutical composition which contains the agent; a method for treating a disease associated with an abnormality in apoptosis, in which the agent is used; and others.
Inventors:
NIITSU YOSHIRO (JP)
TANAKA HIROYUKI (JP)
TANAKA HIROYUKI (JP)
Application Number:
PCT/JP2015/067240
Publication Date:
December 23, 2015
Filing Date:
June 16, 2015
Export Citation:
Assignee:
NITTO DENKO CORP (JP)
International Classes:
A61K45/06; A61K31/7088; A61K31/7105; A61K35/76; A61K48/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| WO2012176282A1 | 2012-12-27 |
Other References:
LI Y. ET AL.: "FIP200 is involved in murine pseudomonas infection by regulating HMGB1 intracellular translocation.", CELL PHYSIOL. BIOCHEM., vol. 3, no. 6, pages 1733 - 1744, XP055375185
CHANO T ET AL.: "RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases.", BRAIN RES., vol. 1168, 2007, pages 97 - 105, XP022242486
BAE H. ET AL.: "Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.", MOL. CANCER RES., vol. 9, no. 9, 2011, pages 1232 - 1241, XP055375189
HOKAIWADO N. ET AL.: "Glutathione S-transferase Pi mediates proliferation of androgen- independent prostate cancer cells.", CARCINOGENESIS, vol. 29, no. 6, 2008, pages 1134 - 1138, XP055141304, DOI: doi:10.1093/carcin/bgn097
YAO J. ET AL.: "Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.", AUTOPHAGY, vol. 11, no. 6, pages 939 - 953, XP055375190
IKEDA T. ET AL.: "Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells.", J. PHARMACOL. SCI., vol. 121, no. 1, 2013, pages 67 - 73, XP055375191
NISHIMURA I. ET AL.: "RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.", J. BIOL. CHEM., vol. 286, no. 51, 2011, pages 43925 - 43932, XP055375239
WEI H. ET AL.: "p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.", GENES DEV., vol. 28, no. 11, pages 1204 - 1216, XP055375240
See also references of EP 3159009A4
CHANO T ET AL.: "RB1CC1 insufficiency causes neuronal atrophy through mTOR signaling alteration and involved in the pathology of Alzheimer's diseases.", BRAIN RES., vol. 1168, 2007, pages 97 - 105, XP022242486
BAE H. ET AL.: "Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.", MOL. CANCER RES., vol. 9, no. 9, 2011, pages 1232 - 1241, XP055375189
HOKAIWADO N. ET AL.: "Glutathione S-transferase Pi mediates proliferation of androgen- independent prostate cancer cells.", CARCINOGENESIS, vol. 29, no. 6, 2008, pages 1134 - 1138, XP055141304, DOI: doi:10.1093/carcin/bgn097
YAO J. ET AL.: "Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.", AUTOPHAGY, vol. 11, no. 6, pages 939 - 953, XP055375190
IKEDA T. ET AL.: "Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells.", J. PHARMACOL. SCI., vol. 121, no. 1, 2013, pages 67 - 73, XP055375191
NISHIMURA I. ET AL.: "RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.", J. BIOL. CHEM., vol. 286, no. 51, 2011, pages 43925 - 43932, XP055375239
WEI H. ET AL.: "p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.", GENES DEV., vol. 28, no. 11, pages 1204 - 1216, XP055375240
See also references of EP 3159009A4
Attorney, Agent or Firm:
MITSUHASHI, Motoki et al. (JP)
Mihashi 規樹 (JP)
Mihashi 規樹 (JP)
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