Title:
APPLICATION OF LOW-MOLECULAR-WEIGHT HYALURONIC ACID FRAGMENTS TO INDUCE STRING AGGREGATION OF RED BLOOD CELLS
Document Type and Number:
WIPO Patent Application WO/2021/180221
Kind Code:
A1
Abstract:
Disclosed is an application of low-molecular-weight hyaluronic acid fragments to induce string aggregation of red blood cells in peripheral blood or venous blood, for use in measuring the molecular weight of low-molecular-weight hyaluronic acid fragments or measuring the molecular weight variation range of products produced between batches. The low-molecular-weight hyaluronic acid fragments having an average molecular weight of 35 kDa induce string aggregation of human red blood cells by combining CD44 on the surface of human red blood cells, for use in activity detection of the low-molecular-weight hyaluronic acid fragments. Further disclosed is that the hyaluronic acid fragments having an average molecular weight of 35 kDa have an inhibitory effect on human neutrophil activation, and can prevent and treat inflammatory diseases related to neutrophil activation and releasing various oxidation substances.
Inventors:
HUI MIZHOU (CN)
SONG LIN (CN)
JIA XIAOXIAO (CN)
HUI JESSICA HANITTA (CN)
WANG FENGWU (CN)
GUO TIANTIAN (CN)
WANG JIAQI (CN)
WU SHUYIN (CN)
CUI JIAYOU (CN)
LI XINRONG (CN)
JIANG YUANYUAN (CN)
SONG LIN (CN)
JIA XIAOXIAO (CN)
HUI JESSICA HANITTA (CN)
WANG FENGWU (CN)
GUO TIANTIAN (CN)
WANG JIAQI (CN)
WU SHUYIN (CN)
CUI JIAYOU (CN)
LI XINRONG (CN)
JIANG YUANYUAN (CN)
Application Number:
PCT/CN2021/080543
Publication Date:
September 16, 2021
Filing Date:
March 12, 2021
Export Citation:
Assignee:
UNIV QINGDAO AGRICULTURAL (CN)
QINGDAO HUINUODE BIOLOGICAL TECH CO LTD (CN)
HUI MIZHOU (CN)
QINGDAO HUINUODE BIOLOGICAL TECH CO LTD (CN)
HUI MIZHOU (CN)
International Classes:
C12N5/078; A61K31/728; A61P29/00; G01N33/86
Domestic Patent References:
| WO2019225895A1 | 2019-11-28 |
Foreign References:
| CN111334468A | 2020-06-26 | |||
| CN111249302A | 2020-06-09 | |||
| CN105018547A | 2015-11-04 | |||
| CN108721320A | 2018-11-02 | |||
| CN103468662A | 2013-12-25 |
Other References:
BELLAR ANNETTE, KESSLER SEAN P., OBERY DANA R., SANGWAN NASEER, WELCH NICOLE, NAGY LAURA E., DASARATHY SRINIVASAN, DE LA MOTTE CAR: "Safety of Hyaluronan 35 in Healthy Human Subjects: A Pilot Study", NUTRIENTS, vol. 11, no. 5, 22 May 2019 (2019-05-22), pages 1 - 13, XP055845114, ISSN: 2072-6643, DOI: 10.3390/nu11051135
JOSÉ LUIS SEBASTIÁN, SAGRARIO MUÑOZ SAN MARTÍN, MIGUEL SANCHO, JOSÉ MIGUEL MIRANDA, AND GABRIEL ÁLVAREZ: "Erythrocyte Rouleau Formation under Polarized Electromagnetic Fields", PHYSICAL REVIEW E (STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS), vol. 72, no. 3, 21 September 2005 (2005-09-21), pages 1 - 9, XP055845110, ISSN: 1539-3755, DOI: 10.1103/PhysRevE.72.031913
CHEN, WEI: "Diagnostic Analysis of a Case of Lymphoma Cell Leukemia with Mature Red Blood Cells in the Shape of "Erythrocyte Rouleaux"", INTERNATIONAL JOURNAL OF LABORATORY MEDICINE, vol. 34, no. 13, 15 July 2013 (2013-07-15), pages 1774, XP009530288, ISSN: 1673-4130
JOSÉ LUIS SEBASTIÁN, SAGRARIO MUÑOZ SAN MARTÍN, MIGUEL SANCHO, JOSÉ MIGUEL MIRANDA, AND GABRIEL ÁLVAREZ: "Erythrocyte Rouleau Formation under Polarized Electromagnetic Fields", PHYSICAL REVIEW E (STATISTICAL, NONLINEAR, AND SOFT MATTER PHYSICS), vol. 72, no. 3, 21 September 2005 (2005-09-21), pages 1 - 9, XP055845110, ISSN: 1539-3755, DOI: 10.1103/PhysRevE.72.031913
CHEN, WEI: "Diagnostic Analysis of a Case of Lymphoma Cell Leukemia with Mature Red Blood Cells in the Shape of "Erythrocyte Rouleaux"", INTERNATIONAL JOURNAL OF LABORATORY MEDICINE, vol. 34, no. 13, 15 July 2013 (2013-07-15), pages 1774, XP009530288, ISSN: 1673-4130
Attorney, Agent or Firm:
BEIJING FINDTO PATENT LAW OFFICE (GENERAL PARTNERSHIP) (CN)
Download PDF:
Previous Patent: IMAGE ENCODING AND DECODING METHOD AND APPARATUS
Next Patent: METHOD FOR CLEANING SILVER EVAPORATION MATERIAL
Next Patent: METHOD FOR CLEANING SILVER EVAPORATION MATERIAL