Title:
APTAMER FOR CHYMASE, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/143714
Kind Code:
A1
Abstract:
An aptamer which can bind to chymase to inhibit the activity of chymase and comprises the nucleotide sequence represented by the formula: X1GAUAGAN1N2UAAX2 (wherein X1 and X2 independently represent A or G; and N1 and N2 independently represent A, G, C, U or T); a complex comprising the aptamer and a functional substance (e.g., an affinity substance, a labeling substance, an enzyme, a drug delivery medium, or a medicinal agent); a medicinal agent or a reagent comprising the aptamer or the complex; a chymase detection method or a chymase purification method characterized by utilizing the aptamer or the complex; and others.
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Inventors:
NAKAMURA YOSHIKAZU (JP)
JIN LING (JP)
YAMAZAKI SATOKO (JP)
IKEDA HISAKO (JP)
MURAGUCHI MASAHIRO (JP)
JIN LING (JP)
YAMAZAKI SATOKO (JP)
IKEDA HISAKO (JP)
MURAGUCHI MASAHIRO (JP)
Application Number:
PCT/JP2010/059953
Publication Date:
December 16, 2010
Filing Date:
June 11, 2010
Export Citation:
Assignee:
RIBOMIC INC (JP)
OTSUKA PHARMA CO LTD (JP)
NAKAMURA YOSHIKAZU (JP)
JIN LING (JP)
YAMAZAKI SATOKO (JP)
IKEDA HISAKO (JP)
MURAGUCHI MASAHIRO (JP)
OTSUKA PHARMA CO LTD (JP)
NAKAMURA YOSHIKAZU (JP)
JIN LING (JP)
YAMAZAKI SATOKO (JP)
IKEDA HISAKO (JP)
MURAGUCHI MASAHIRO (JP)
International Classes:
C12N15/09; A61P9/00; A61P19/04; A61P43/00; C12Q1/68; A61K31/7088
Domestic Patent References:
| WO1991019813A1 | 1991-12-26 | |||
| WO1994008050A1 | 1994-04-14 | |||
| WO1995007364A1 | 1995-03-16 |
Foreign References:
| US6500835B2 | 2002-12-31 | |||
| US6500835B2 | 2002-12-31 | |||
| US5660985A | 1997-08-26 |
Other References:
ZHAO XIAO-YAN ET AL.: "Chymase induces profibrotic response via transforming growth factor-beta1/Smad activation in rat cardiac fibroblasts.", MOL. CELL BIOCHEM., vol. 310, 2008, pages 159 - 166, XP019578357
KANEMITSU HIDEO ET AL.: "Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats.", EUR. J. CARDIOTHORAC. SURG., vol. 33, 2008, pages 25 - 31, XP022394016
PALANIYANDI S. SURESH ET AL.: "Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats.", EXP. BIOL. MED., vol. 232, 2007, pages 1213 - 1221, XP008148888
SHIOTA NAOTAKA ET AL.: "Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice.", BR. J. PHARMACOL., vol. 145, 2005, pages 424 - 431, XP008148904
SHIN MIYAGAWA: "Development of RNA aptamers for therapeutics", DRUG DELIV. SYST., vol. 23, no. 5, 2008, pages 534 - 543, XP008148889
TOSHIO IWAKAWA: "RNA Aptamer no Kaihatsu to Iyakuhin eno Oyo", MEDICAL SCIENCE DIGEST, vol. 35, no. L, January 2009 (2009-01-01), pages 5 - 6, XP008150068
MASATOSHI FUJIWARA: "Kakusan Soyaku no Kaihatsu Jokyo", JIKKEN IGAKU, vol. 27, no. 5, March 2009 (2009-03-01), pages 179 - 185, XP008150654
SPROAT ET AL., NUCLE. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
NUCLEIC ACID, vol. 2
YUKIO SUGIURA: "Synthesis and Analysis of Nucleic Acid", HIROKAWA PUBLISHING COMPANY
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ELLINGTON; SZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK; GOLD, SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
See also references of EP 2441833A4
KANEMITSU HIDEO ET AL.: "Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats.", EUR. J. CARDIOTHORAC. SURG., vol. 33, 2008, pages 25 - 31, XP022394016
PALANIYANDI S. SURESH ET AL.: "Chymase inhibition reduces the progression to heart failure after autoimmune myocarditis in rats.", EXP. BIOL. MED., vol. 232, 2007, pages 1213 - 1221, XP008148888
SHIOTA NAOTAKA ET AL.: "Effect of mast cell chymase inhibitor on the development of scleroderma in tight-skin mice.", BR. J. PHARMACOL., vol. 145, 2005, pages 424 - 431, XP008148904
SHIN MIYAGAWA: "Development of RNA aptamers for therapeutics", DRUG DELIV. SYST., vol. 23, no. 5, 2008, pages 534 - 543, XP008148889
TOSHIO IWAKAWA: "RNA Aptamer no Kaihatsu to Iyakuhin eno Oyo", MEDICAL SCIENCE DIGEST, vol. 35, no. L, January 2009 (2009-01-01), pages 5 - 6, XP008150068
MASATOSHI FUJIWARA: "Kakusan Soyaku no Kaihatsu Jokyo", JIKKEN IGAKU, vol. 27, no. 5, March 2009 (2009-03-01), pages 179 - 185, XP008150654
SPROAT ET AL., NUCLE. ACID. RES., vol. 19, 1991, pages 733 - 738
COTTON ET AL., NUCL. ACID. RES., vol. 19, 1991, pages 2629 - 2635
HOBBS ET AL., BIOCHEMISTRY, vol. 12, 1973, pages 5138 - 5145
NUCLEIC ACID, vol. 2
YUKIO SUGIURA: "Synthesis and Analysis of Nucleic Acid", HIROKAWA PUBLISHING COMPANY
ELLINGTON ET AL., NATURE, vol. 346, 1990, pages 818 - 822
TUERK ET AL., SCIENCE, vol. 249, 1990, pages 505 - 510
ELLINGTON; SZOSTAK, NATURE, vol. 346, 1990, pages 818 - 822
TUERK; GOLD, SCIENCE, vol. 249, 1990, pages 505 - 510
M. ZUKER, NUCLEIC ACIDS RES., vol. 31, no. 13, 2003, pages 3406 - 3415
See also references of EP 2441833A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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