Title:
APTAMERS TO THE HUMAN IL-12 CYTOKINE FAMILY AND THEIR USE AS AUTOIMMUNE DISEASE THERAPEUTICS
Document Type and Number:
WIPO Patent Application WO2005086835
Kind Code:
A3
Abstract:
The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
Inventors:
DIENER JOHN L (US)
FERGUSON ALICIA (US)
HAMAGUCHI NOBUKO (US)
KEENE SARA CHESWORTH (US)
LAGASSE H A DANIEL (US)
SAWHNEY POOJA (US)
THOMPSON KRISTIN (US)
FERGUSON ALICIA (US)
HAMAGUCHI NOBUKO (US)
KEENE SARA CHESWORTH (US)
LAGASSE H A DANIEL (US)
SAWHNEY POOJA (US)
THOMPSON KRISTIN (US)
Application Number:
PCT/US2005/007666
Publication Date:
December 21, 2006
Filing Date:
March 07, 2005
Export Citation:
Assignee:
ARCHEMIX CORP (US)
DIENER JOHN L (US)
FERGUSON ALICIA (US)
HAMAGUCHI NOBUKO (US)
KEENE SARA CHESWORTH (US)
LAGASSE H A DANIEL (US)
SAWHNEY POOJA (US)
THOMPSON KRISTIN (US)
DIENER JOHN L (US)
FERGUSON ALICIA (US)
HAMAGUCHI NOBUKO (US)
KEENE SARA CHESWORTH (US)
LAGASSE H A DANIEL (US)
SAWHNEY POOJA (US)
THOMPSON KRISTIN (US)
International Classes:
C07H21/04; C12N15/115
Foreign References:
| US20040197804A1 | 2004-10-07 | |||
| US5571515A | 1996-11-05 | |||
| US5994104A | 1999-11-30 | |||
| US6610285B1 | 2003-08-26 |
Other References:
CORDOBA-RODRIQUEZ R. ET AL.: "IL-23 and IL-27: New Members of the Growing Family of IL-12-Related Cytokines with Important Implications for Therapeutics", vol. 3, 2003, pages 715 - 723, XP009048344
DATABASE GENBANK [online] XP003004963, Database accession no. (NM_016584)
DATABASE GENBANK [online] 26 September 1999 (1999-09-26), XP003004964, Database accession no. (AF180563)
BURGSTALLER P. ET AL.: "Aptamers and Aptazymes: Accelerating Small Molecule Drug Discovery", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 5, 2002, pages 690 - 700, XP009032914
VANDENBROECK ET AL.: "Inhibiting Cytokines of the Interleukin-12 Family: Recent Advances and Novel Challenges", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 56, 2004, pages 145 - 160, XP008074541
DATABASE GENBANK [online] XP003004963, Database accession no. (NM_016584)
DATABASE GENBANK [online] 26 September 1999 (1999-09-26), XP003004964, Database accession no. (AF180563)
BURGSTALLER P. ET AL.: "Aptamers and Aptazymes: Accelerating Small Molecule Drug Discovery", CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, vol. 5, 2002, pages 690 - 700, XP009032914
VANDENBROECK ET AL.: "Inhibiting Cytokines of the Interleukin-12 Family: Recent Advances and Novel Challenges", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 56, 2004, pages 145 - 160, XP008074541
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