Title:
ARYL SULFIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/073183
Kind Code:
A1
Abstract:
It is intended to provide a compound which has an effect of inhibiting the adhesion of LFA-1 to its ligand ICAM-1 and is useful in preventing or treating inflammatory diseases and autoimmune diseases, in particular, rheumatoid arthritis, asthma, psoriasis, inflammatory bowel disease, multiple sclerosis, nephritis, rejection in transplantation, etc. An aryl sulfide derivative, in which a cyclic group such as piperidine is attached to the 4-position via a specific linker such as carbamate, or its salt.
Inventors:
INAMI HIROSHI (JP)
KAWAGUCHI KENICHI (JP)
KUBOTA HIROKAZU (JP)
YAMASAKI SHINGO (JP)
MATSUZAWA TAKAHO (JP)
KAGA DAISUKE (JP)
SEKI NORIO (JP)
MORIO HIROKI (JP)
KAWAGUCHI KENICHI (JP)
KUBOTA HIROKAZU (JP)
YAMASAKI SHINGO (JP)
MATSUZAWA TAKAHO (JP)
KAGA DAISUKE (JP)
SEKI NORIO (JP)
MORIO HIROKI (JP)
Application Number:
PCT/JP2005/001550
Publication Date:
August 11, 2005
Filing Date:
January 27, 2005
Export Citation:
Assignee:
YAMANOUCHI PHARMA CO LTD (JP)
INAMI HIROSHI (JP)
KAWAGUCHI KENICHI (JP)
KUBOTA HIROKAZU (JP)
YAMASAKI SHINGO (JP)
MATSUZAWA TAKAHO (JP)
KAGA DAISUKE (JP)
SEKI NORIO (JP)
MORIO HIROKI (JP)
INAMI HIROSHI (JP)
KAWAGUCHI KENICHI (JP)
KUBOTA HIROKAZU (JP)
YAMASAKI SHINGO (JP)
MATSUZAWA TAKAHO (JP)
KAGA DAISUKE (JP)
SEKI NORIO (JP)
MORIO HIROKI (JP)
International Classes:
A61K31/165; A61K31/27; A61K31/341; A61K31/351; A61K31/382; A61K31/395; A61K31/40; A61K31/401; A61K31/4166; A61K31/438; A61K31/439; A61K31/44; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4468; A61K31/451; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/4965; A61K31/505; A61K31/5377; A61K31/541; C07C323/19; C07C323/20; C07C323/40; C07C323/62; (IPC1-7): C07C323/20; A61K31/165; A61K31/27; A61K31/341; A61K31/351; A61K31/382; A61K31/395; A61K31/40; A61K31/401; A61K31/4166; A61K31/438; A61K31/439; A61K31/44; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4468; A61K31/451; A61K31/453; A61K31/4535; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/4965; A61K31/505; A61K31/5375; A61K31/5377; A61K31/541; A61P1/00; A61P7/02; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07C323/22; C07C323/40; C07C323/60; C07D207/14; C07D207/16; C07D207/27; C07D207/333; C07D209/08; C07D209/14; C07D211/22; C07D211/26; C07D211/34; C07D211/42; C07D211/46; C07D211/58; C07D211/60; C07D211/62; C07D211/66; C07D211/74; C07D211/78; C07D213/40; C07D213/64; C07D213/70; C07D213/74; C07D213/75; C07D213/82; C07D215/36; C07D233/60; C07D233/61; C07D233/74; C07D239/38; C07D241/04; C07D241/08; C07D243/08; C07D265/30; C07D277/06; C07D277/20; C07D277/44; C07D295/08; C07D295/12; C07D295/14; C07D295/18; C07D295/20; C07D295/22; C07D305/04; C07D307/12; C07D307/16; C07D307/22; C07D307/32; C07D307/52; C07D307/54; C07D309/06; C07D309/14; C07D309/20; C07D317/34; C07D319/18; C07D335/02; C07D401/04; C07D401/12; C07D405/12; C07D407/12; C07D409/06; C07D413/04; C07D451/04; C07D453/02; C07D471/04; C07D471/10
Domestic Patent References:
| WO2003029205A1 | 2003-04-10 |
Foreign References:
| JP2002533434A | 2002-10-08 | |||
| JPS5422333A | 1979-02-20 |
Attorney, Agent or Firm:
Morita, Hiroshi c/o Yamanouchi Pharmaceutical Co. Ltd. (Patent Department, 17-1, Hasune 3-chom, Itabashi-ku Tokyo 12, JP)
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