Title:
ARYLALKYL-PIPERAZINE DERIVATIVES FOR THE TREATMENT OF CONDITIONS AMELIORATED BY MONOAMINE REUPTAKE INCLUDING VASOMOTOR SYMPTOMS (VMS)
Document Type and Number:
WIPO Patent Application WO2005037207
Kind Code:
A3
Abstract:
The present invention is directed to alkanoyl and cycloalkanoyl-amine derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, nc gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibrornyalgia, pain, diabetic neuropathy, and combinations thereof.
Inventors:
TRYBULSKI EUGENE JOHN (US)
MAHANEY PAIGE ERIN (US)
KRIM LORI DANIELLE (US)
MOORE WILLIAM JAY (US)
SABATUCCI JOSEPH PETER (US)
MAHANEY PAIGE ERIN (US)
KRIM LORI DANIELLE (US)
MOORE WILLIAM JAY (US)
SABATUCCI JOSEPH PETER (US)
Application Number:
PCT/US2004/033730
Publication Date:
September 21, 2006
Filing Date:
October 13, 2004
Export Citation:
Assignee:
WYETH CORP (US)
TRYBULSKI EUGENE JOHN (US)
MAHANEY PAIGE ERIN (US)
KRIM LORI DANIELLE (US)
MOORE WILLIAM JAY (US)
SABATUCCI JOSEPH PETER (US)
TRYBULSKI EUGENE JOHN (US)
MAHANEY PAIGE ERIN (US)
KRIM LORI DANIELLE (US)
MOORE WILLIAM JAY (US)
SABATUCCI JOSEPH PETER (US)
International Classes:
C07D295/092; A61K31/495; A61K31/496; C07D207/14; C07D209/14; C07D211/44; C07D211/46; C07D211/48; C07D211/56; C07D211/58; C07D213/38; C07D215/12; C07D215/14; C07D243/08; C07D295/073; C07D295/084; C07D295/096; C07D295/155; C07D307/52; C07D307/81; C07D309/10; C07D317/58; C07D333/20; C07D333/38; C07D333/58; C07D409/06; C07D471/04; A61K
Domestic Patent References:
| WO2004035058A1 | 2004-04-29 | |||
| WO2004035036A1 | 2004-04-29 | |||
| WO2004035035A1 | 2004-04-29 | |||
| WO2005037807A1 | 2005-04-28 |
Foreign References:
| EP0310268A2 | 1989-04-05 | |||
| DE2006433A1 | 1970-10-01 | |||
| US2971955A | 1961-02-14 | |||
| EP1295608A1 | 2003-03-26 |
Other References:
STEARNS V ET AL: "Hot flushes", LANCET, XX, XX, vol. 360, no. 9348, 7 December 2002 (2002-12-07), pages 1851 - 1861, XP004397574, ISSN: 0140-6736
LOPRINZI C L ET AL: "PILOT EVALUATION OF VENLAFAXINE HYDROCHLORIDE FOR THE THERAPY OF HOT FLASHES IN CANCER SURVIVORS", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 16, no. 7, July 1998 (1998-07-01), pages 2377 - 2381, XP000997950, ISSN: 0732-183X
LOPRINZI C L ET AL: "PILOT EVALUATION OF VENLAFAXINE HYDROCHLORIDE FOR THE THERAPY OF HOT FLASHES IN CANCER SURVIVORS", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 16, no. 7, July 1998 (1998-07-01), pages 2377 - 2381, XP000997950, ISSN: 0732-183X
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