Title:
BENZAMIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2001/062718
Kind Code:
A1
Abstract:
A compound represented by the general formula (I), a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof. In said formula A is optionally substituted 3-sulfamoylphenyl, optionally substituted 2-thienyl, etc.; R¿10? is hydrogen or optionally substituted lower alkyl; R¿11? is hydrogen, halogeno, or hydroxy; R¿12? is hydrogen, halogeno, or nitro; R¿13? is hydroxy, optionally substituted lower alkoxy, optionally substituted lower alkylamino, etc.; R¿14? is hydrogen, halogeno, nitro, etc.; and R¿15? is hydrogen, halogeno, or hydroxy. The compound (I) has an excellent antagonistic effect on a CRF receptor. Therefore, it is expected to be a preventive or remedy for, e.g., diseases to be caused or worsened by a CRF.
Inventors:
SATO MOTOHIDE (JP)
HARADA KAZUHITO (JP)
MIYAZAKI AKIRA (JP)
HARADA KAZUHITO (JP)
MIYAZAKI AKIRA (JP)
Application Number:
PCT/JP2001/001429
Publication Date:
August 30, 2001
Filing Date:
February 26, 2001
Export Citation:
Assignee:
JAPAN TOBACCO INC (JP)
SATO MOTOHIDE (JP)
HARADA KAZUHITO (JP)
MIYAZAKI AKIRA (JP)
SATO MOTOHIDE (JP)
HARADA KAZUHITO (JP)
MIYAZAKI AKIRA (JP)
International Classes:
A61P5/42; A61P9/12; A61P25/00; C07C311/46; C07C311/47; C07C317/40; C07C323/67; C07D265/36; C07D295/26; C07D307/79; C07D311/58; C07D311/70; C07D333/38; C07F9/12; (IPC1-7): C07C311/46; A61K31/18; A61K31/215; A61K31/343; A61K31/353; A61K31/381; A61K31/40; A61K31/4453; A61K31/495; A61K31/538; A61P5/42; A61P9/12; A61P25/00; C07C311/47; C07D207/34; C07D265/36; C07D295/08; C07D295/18; C07D295/22; C07D307/79; C07D311/70; C07D333/38; C07D333/40; C07F9/09
Domestic Patent References:
| WO1999012908A1 | 1999-03-18 | |||
| WO1998005661A1 | 1998-02-12 | |||
| WO1997035580A1 | 1997-10-02 | |||
| WO1997014684A1 | 1997-04-24 | |||
| WO1997000868A1 | 1997-01-09 | |||
| WO1994013661A1 | 1994-06-23 |
Foreign References:
| EP0261503A1 | 1988-03-30 |
Attorney, Agent or Firm:
Iwatani, Ryo (5F 1-27, Dojima 2-chome Kita-ku Osaka-shi Osaka, JP)
Download PDF: