BENZOIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Title:

BENZOIC ACID DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2001/062708

Kind Code:

A1

Abstract:

Benzoic acid derivatives represented by the general formula (I), nontoxic salts thereof, a process for producing the same and drugs containing the same as the active ingredient; (I) wherein A, B, R?6¿ and R?7¿ represent each a carbon ring, a heterocycle, etc.; R?1¿ represents hydroxy, etc.; R?2¿, R?3¿ and R?4¿ represent each alkyl, etc.; R?5¿, D and E represent each alkylene, etc.; and G represents oxygen, etc. Because of strongly binding particularly to the subtype EP¿4? of PGE¿2? receptor, the compounds represented by the general formula (I) are expected as useful in preventing and/or treating bone diseases, cancer, systemic granuloma, immunologic diseases, allergy, atopy, asthma, alveolar abscess, gingivitis, peridontosis, nerve cell death, Alzheimer's disease, lung disorder, liver disorder, acute hepatitis, nephritis, renal insufficiency, myocardial ischemia, Kawasaki's disease, burn, ulcerative colitis, Crohn's disease, multiple failure, etc. and diseases in association with sleep failure or platelet aggregation.

Inventors:

TANI KOUSUKE (JP)
KOBAYASHI KAORU (JP)
MARUYAMA TAKAYUKI (JP)

Application Number:

PCT/JP2001/001263

Publication Date:

August 30, 2001

Filing Date:

February 21, 2001

Export Citation:

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Assignee:

ONO PHARMACEUTICAL CO (JP)
TANI KOUSUKE (JP)
KOBAYASHI KAORU (JP)
MARUYAMA TAKAYUKI (JP)

International Classes:

C07C233/55; C07C235/38; C07C235/84; C07C255/60; C07C323/62; C07D213/30; C07D213/75; C07D213/80; C07D215/06; C07D215/12; C07D215/14; C07D263/34; C07D307/68; C07D333/38; (IPC1-7): C07C233/29; A61K31/196; A61K31/277; A61K31/381; A61K31/421; A61K31/44; A61K31/4402; A61K31/4409; A61K31/47; A61P1/02; A61P1/16; A61P7/02; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P25/00; A61P25/20; A61P25/28; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07C231/02; C07C231/12; C07C233/55; C07C253/30; C07C255/60; C07C319/20; C07C323/62; C07C323/63; C07D213/75; C07D213/80; C07D215/06; C07D215/12; C07D263/34; C07D333/40

Foreign References:

US5447957A	1995-09-05
DE2510260A1	1976-09-23

Other References: