Title:
BIARYL COMPOUND, PROCESS FOR PRODUCING THE SAME, AND AGENT
Document Type and Number:
WIPO Patent Application WO/2002/055484
Kind Code:
A1
Abstract:
A compound represented by the formula (I) [wherein rings A and B each represents an optionally substituted five- or six-membered aromatic ring; R?1¿ and R?2¿ each represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group; X?1¿, X?2¿, X?3¿, and X?4¿ each represents a bond or an optionally substituted divalent hydrocarbon group; Y represents -NR?3¿-CO-, -CO-NR?3¿-, -NR?3¿-SO¿2?-, -SO¿2?-NR?3¿-, -NR?3¿-CH¿2?- (R?3¿ represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group), etc.; Z represents -CO-NH-, -CS-NH-, -CO-, or -SO¿2?-; and Ar represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group] or a salt of the compound. The compound or salt functions to increase the amount of a low-density lipoprotein (LDL) receptor and is useful as a blood lipid depressant, etc. Also provided is a medicine or the like containing the compound or salt.
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Inventors:
KORI MASAKUNI (JP)
ISHIKAWA EIICHIRO (JP)
NAKATA MIKIYO (JP)
KOBAYASHI MAKOTO (JP)
ISHIKAWA EIICHIRO (JP)
NAKATA MIKIYO (JP)
KOBAYASHI MAKOTO (JP)
Application Number:
PCT/JP2002/000073
Publication Date:
July 18, 2002
Filing Date:
January 10, 2002
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
KORI MASAKUNI (JP)
ISHIKAWA EIICHIRO (JP)
NAKATA MIKIYO (JP)
KOBAYASHI MAKOTO (JP)
KORI MASAKUNI (JP)
ISHIKAWA EIICHIRO (JP)
NAKATA MIKIYO (JP)
KOBAYASHI MAKOTO (JP)
International Classes:
A61P3/06; A61P3/10; A61P9/10; C07C311/18; C07D213/40; C07D213/75; C07D213/81; C07D213/82; C07D307/14; C07D333/20; C07D401/12; C07D405/12; C07D409/12; C07D417/12; (IPC1-7): C07C233/78; A61K31/17; A61K31/341; A61K31/381; A61K31/4402; A61K31/4406; A61K31/443; A61K31/4436; A61K31/506; A61P3/06; A61P3/10; A61P9/10; C07C233/80; C07C271/08; C07C271/40; C07C275/28; C07C311/01; C07C311/15; C07C311/30; C07C335/16; C07D213/40; C07D213/56; C07D213/75; C07D213/81; C07D213/82; C07D307/52; C07D333/20; C07D401/12; C07D405/12; C07D409/12
Domestic Patent References:
| WO1999012534A1 | 1999-03-18 |
Foreign References:
| EP0665216A1 | 1995-08-02 |
Attorney, Agent or Firm:
Takahashi, Shuichi c/o Osaka Plant of Takeda Chemical Industries (Ltd. 17-85 Jusohonmachi 2-chome Yodogawa-ku Osaka-shi, Osaka, JP)
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