Title:
BICYCLIC HETEROCYCLES, DRUGS CONTAINING SAID COMPOUNDS, THE USE THEREOF AND METHOD FOR PREPARING THE SAME
Document Type and Number:
WIPO Patent Application WO2004108664
Kind Code:
A3
Abstract:
The invention relates to the bicyclic heterocycles of general formula (I), wherein R, R, R, R, X and n are defined as in claim 1, to their tautomers, stereoisomers, mixtures and salts thereof, especially the physiologically acceptable salts thereof with inorganic or organic acids. The inventive compounds have valuable pharmacological properties, especially they inhibit tyrosinkinase-mediated signal transduction. The invention also relates to the use of said compounds for treating diseases, especially tumor diseases and benign prostatic hyperplasia (BPH), diseases of the lung and respiratory tracts, and to the production of these compounds.
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Inventors:
HIMMELSBACH FRANK (DE)
SOYKA RAINER (DE)
JUNG BIRGIT (DE)
SOYKA RAINER (DE)
JUNG BIRGIT (DE)
Application Number:
PCT/EP2004/005965
Publication Date:
May 26, 2005
Filing Date:
June 02, 2004
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT (DE)
BOEHRINGER INGELHEIM PHARMA (DE)
HIMMELSBACH FRANK (DE)
SOYKA RAINER (DE)
JUNG BIRGIT (DE)
BOEHRINGER INGELHEIM PHARMA (DE)
HIMMELSBACH FRANK (DE)
SOYKA RAINER (DE)
JUNG BIRGIT (DE)
International Classes:
A61K31/422; A61K31/4709; A61K31/517; A61P35/00; C07D239/94; C07D413/12; C07D; (IPC1-7): C07D239/94; C07D413/12; A61K31/517; A61K31/422; A61P35/00
Domestic Patent References:
| WO2002018351A1 | 2002-03-07 | |||
| WO2000055141A1 | 2000-09-21 | |||
| WO1996033980A1 | 1996-10-31 |
Other References:
BARKER, A. J. ET AL: "Studies leading to the identification of ZD1839 (iressa): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS , 11(14), 1911-1914 CODEN: BMCLE8; ISSN: 0960-894X, 2001, XP002303977
KASHIMA, CHOJI; HARADA, KAZUO: "Synthesis and Reaction of Optically Active Morpholinones", J. CHEM. SOC. PERKIN TRANS. 1, 1988, pages 1521 - 1526, XP009044168
GORE, JEFF ET AL.: "The Structure of a Human Metabolite of Pholcodine", AUST. J. CHEM., vol. 49, no. 11, 1996, pages 1235 - 1242, XP009044167
KASHIMA, CHOJI; HARADA, KAZUO: "Synthesis and Reaction of Optically Active Morpholinones", J. CHEM. SOC. PERKIN TRANS. 1, 1988, pages 1521 - 1526, XP009044168
GORE, JEFF ET AL.: "The Structure of a Human Metabolite of Pholcodine", AUST. J. CHEM., vol. 49, no. 11, 1996, pages 1235 - 1242, XP009044167
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