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Title:
BRANCHED MONODISPERSED POLYETHYLENE GLYCOL, INTERMEDIATE, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/181984
Kind Code:
A1
Abstract:
Branched monodispersed polyethylene glycol represented by formula (1). (X1 is a functional group that reacts with a functional group present in a biofunctional molecule to form a covalent bond; n is an integer of 4-50 and represents the number of repeating units of ethylene oxide units; L1 represents a single bond, -NH-, -L2-(CH2)m1-, or -L2-(CH2)m1-L3-(CH2)m2-; L2 represents an ether bond, an amide bond, a urethane bond, or a single bond; L3 represents an ether bond, an amide bond, or a urethane bond; and m1 and m2 each independently represent an integer of 1-5.)

Inventors:
HAMURA MIKA (JP)
MATSUNO YUKI (JP)
YOSHIOKA HIROKI (JP)
Application Number:
PCT/JP2019/011594
Publication Date:
September 26, 2019
Filing Date:
March 19, 2019
Export Citation:
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Assignee:
NOF CORP (JP)
International Classes:
C07C43/13; C07C41/18; C07D207/46; C08G65/329
Domestic Patent References:
WO2017057612A12017-04-06
Foreign References:
JP2012528857A2012-11-15
JP2008500375A2008-01-10
JP2004197077A2004-07-15
US20130052130A12013-02-28
JP2018052365A2018-04-05
Other References:
SCHUSTER, T. ET AL.: "Effects of chemical structure on the dynamic and static surface tensions of short-chain, multi-arm nonionic fluorosurfactants", JOURNAL OF COLLOID AND INTERFACE SCIENCE, vol. 428, 2014, pages 276 - 285, XP028850056
HERMANSON, G. T.: "Bioconjugate Techniques", 2008, ACADEMIC PRESS
HARRIS, J. M.: "Poly(Ethylene Glycol) Chemistry", 1992, PLENUM PRESS
"PEGylated Protein Drugs: Basic Science and Clinical Applications", 2009, BIRKHAUSER
See also references of EP 3770143A4
Attorney, Agent or Firm:
KOH-EI PATENT FIRM, P.C. (JP)
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