Title:
CANDIDA UTILIS CONTAINING &gammad -GLUTAMYLCYSTEINE
Document Type and Number:
WIPO Patent Application WO/2003/080832
Kind Code:
A1
Abstract:
A food containing &gammad -glutamylcysteine or cysteine is produced by culturing under appropriate conditions Candida utilis containing 1% by weight or more of &gammad -glutamylcysteine based on dry cells in the logarithmic growth phase when cultured in the minimum medium (for example, Candida utilis carrying a gene encoding glutathione synthase which has been modified so as to lower the glutathione synthase activity in the cells), adding the thus obtained culture or a fraction thereof optionally after heating to a food or drink material, and then processing.
Inventors:
NISHIUCHI HIROAKI (JP)
NISHIMURA YASUSHI (JP)
KURODA MOTONAKA (JP)
NISHIMURA YASUSHI (JP)
KURODA MOTONAKA (JP)
Application Number:
PCT/JP2003/003715
Publication Date:
October 02, 2003
Filing Date:
March 26, 2003
Export Citation:
Assignee:
AJINOMOTO KK (JP)
NISHIUCHI HIROAKI (JP)
NISHIMURA YASUSHI (JP)
KURODA MOTONAKA (JP)
NISHIUCHI HIROAKI (JP)
NISHIMURA YASUSHI (JP)
KURODA MOTONAKA (JP)
International Classes:
A23L1/28; A23L1/30; A23L1/305; A23L27/10; A23L27/24; C12N1/19; C12N9/00; C12P13/04; (IPC1-7): C12N15/09; A23L1/221; C12N1/16; C12N1/19; A23L1/28
Domestic Patent References:
| WO2001090310A1 | 2001-11-29 | |||
| WO1998014600A1 | 1998-04-09 | |||
| WO2000030474A1 | 2000-06-02 | |||
| WO2001090310A1 | 2001-11-29 |
Foreign References:
| JPS6152299A | 1986-03-14 | |||
| JPS6131081A | 1986-02-13 | |||
| JPH0491762A | 1992-03-25 | |||
| JPH0318872B2 | 1991-03-13 | |||
| JPS6152299A | 1986-03-14 | |||
| JPS6131081A | 1986-02-13 |
Other References:
YASUYUKI OTAKE ET AL.: "Glutathione koseisan kobo no ikushu", BIOSCIENCE & INDUSTRY, vol. 50, no. 10, 1992, pages 989 - 994, XP002970454
MUTOH N. ET AL.: "Molecular cloning and nucleotide sequencing of the gamma-glkutamylcysteine synthetase gene of the fission yeast schizosaccharomyces pombe", J. BIOCHEM., vol. 117, no. 2, 1995, TOKYO, pages 283 - 288, XP002970455
WU A.L. ET AL.: "GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for gammaAP-1 transcriptional regulation", MOL. CELL BIOL., vol. 14, no. 9, 1994, pages 5832 - 5839, XP002970456
OHTAKE Y. ET AL.: "Molecular cloning of the gamma-glutamylcysteine synthetase gene of saccharomyces cerevisiae", YEAST, vol. 7, no. 9, 1991, pages 953 - 961, XP002970457
ROBINS R.J. ET AL.: "The role of glutathione in amino-acid absorption. Lack of correlation between glutathione turnover and amino-acid absorption by the yeast candida utilis", BIOCHEM. J., vol. 194, no. 1, 1981, pages 63 - 70, XP002970458
BIOTECHNOLOGY, vol. 3, 1983, pages 30
KONDO ET AL., J. BACTERIOLOGY, December 1995 (1995-12-01), pages 7171 - 7177
OHTAKE Y. ET AL.: "Molecular cloning of the gamma-glutamylcysteine synthetase gene of saccharomyces cerevisiae", YEAST, vol. 7, no. 9, 1991, pages 953 - 961, XP002970457, DOI: doi:10.1002/yea.320070907
MUTOH N. ET AL.: "Molecular cloning and nucleotide sequencing of the gamma-glutamylcysteine synthetase gene of the fission yeast schizosaccharomyces pombe", J. BIOCHEM., vol. 117, no. 2, 1995, pages 283 - 288, XP002970455, DOI: doi:10.1093/jb/117.2.283
K. KONDO ET AL., J. BACTERIOL., vol. 177, 1995, pages 7171 - 7177
MUTOH N. ET AL.: "Molecular cloning and nucleotide sequencing of the gamma-glkutamylcysteine synthetase gene of the fission yeast schizosaccharomyces pombe", J. BIOCHEM., vol. 117, no. 2, 1995, TOKYO, pages 283 - 288, XP002970455
WU A.L. ET AL.: "GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for gammaAP-1 transcriptional regulation", MOL. CELL BIOL., vol. 14, no. 9, 1994, pages 5832 - 5839, XP002970456
OHTAKE Y. ET AL.: "Molecular cloning of the gamma-glutamylcysteine synthetase gene of saccharomyces cerevisiae", YEAST, vol. 7, no. 9, 1991, pages 953 - 961, XP002970457
ROBINS R.J. ET AL.: "The role of glutathione in amino-acid absorption. Lack of correlation between glutathione turnover and amino-acid absorption by the yeast candida utilis", BIOCHEM. J., vol. 194, no. 1, 1981, pages 63 - 70, XP002970458
BIOTECHNOLOGY, vol. 3, 1983, pages 30
KONDO ET AL., J. BACTERIOLOGY, December 1995 (1995-12-01), pages 7171 - 7177
OHTAKE Y. ET AL.: "Molecular cloning of the gamma-glutamylcysteine synthetase gene of saccharomyces cerevisiae", YEAST, vol. 7, no. 9, 1991, pages 953 - 961, XP002970457, DOI: doi:10.1002/yea.320070907
MUTOH N. ET AL.: "Molecular cloning and nucleotide sequencing of the gamma-glutamylcysteine synthetase gene of the fission yeast schizosaccharomyces pombe", J. BIOCHEM., vol. 117, no. 2, 1995, pages 283 - 288, XP002970455, DOI: doi:10.1093/jb/117.2.283
K. KONDO ET AL., J. BACTERIOL., vol. 177, 1995, pages 7171 - 7177
Attorney, Agent or Firm:
Kawaguchi, Yoshiyuki (4-10 Higashi Nihonbashi 3-chom, Chuo-ku Tokyo, JP)
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