Title:
COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF HIF-1 ALPHA
Document Type and Number:
WIPO Patent Application WO2004042024
Kind Code:
A3
Abstract:
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is also inhibited. Control of VEGF production through siRNA-mediated down-regulation of HIF-1 alpha can be used to inhibit angiogenesis, in particularly in diseases such as diabetic retinopathy, age related macular degeneration and many types of cancer.
More Like This:
Inventors:
REICH SAMUEL JOTHAM (US)
SURACE ENRICO MARIA (IT)
TOLENTINO MICHAEL J (US)
SURACE ENRICO MARIA (IT)
TOLENTINO MICHAEL J (US)
Application Number:
PCT/US2003/034826
Publication Date:
September 23, 2004
Filing Date:
October 31, 2003
Export Citation:
Assignee:
UNIV PENNSYLVANIA (US)
REICH SAMUEL JOTHAM (US)
SURACE ENRICO MARIA (IT)
TOLENTINO MICHAEL J (US)
REICH SAMUEL JOTHAM (US)
SURACE ENRICO MARIA (IT)
TOLENTINO MICHAEL J (US)
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K48/00; C12N15/00
Other References:
SUN ET AL: "Gene Transfer of Antisense Hypoxia Inductible Factor-1 alpha Enhances the Therapeutic Efficacy of Cancer Immunotherapy", GENE THERAPY, vol. 8, 2001, pages 638 - 645, XP001154043
KANG ET AL: "An Antisense Oligonucleotide That Inhibits the Expression of Hypoxia-Inductible Factor-1 alpha Alters Hypoxia-Induced Changes in Proliferation and Viability of Human Cardiac Fibroblasts", CIRCULATION, AMERICAN HEART ASSOCIATION, vol. 104, no. 17, SUPPL, 23 October 2001 (2001-10-23), pages II.57, XP009015505
HOEG ET AL: "In vitro and in vivo Efficacy of a HIF-1alpha-Antisense Oligonucleotide Containing Locked Nucleic Acids", ECJ SUPPLEMENTS, September 2003 (2003-09-01), pages S212 - S213, XP002978455
KANG ET AL: "An Antisense Oligonucleotide That Inhibits the Expression of Hypoxia-Inductible Factor-1 alpha Alters Hypoxia-Induced Changes in Proliferation and Viability of Human Cardiac Fibroblasts", CIRCULATION, AMERICAN HEART ASSOCIATION, vol. 104, no. 17, SUPPL, 23 October 2001 (2001-10-23), pages II.57, XP009015505
HOEG ET AL: "In vitro and in vivo Efficacy of a HIF-1alpha-Antisense Oligonucleotide Containing Locked Nucleic Acids", ECJ SUPPLEMENTS, September 2003 (2003-09-01), pages S212 - S213, XP002978455
Download PDF:
Previous Patent: STEM CELL LIBRARIES
Next Patent: CELL-SPECIFIC ADENOVIRUS VECTOR COMPRISING EBV-SPECIFIC PROMOTER
Next Patent: CELL-SPECIFIC ADENOVIRUS VECTOR COMPRISING EBV-SPECIFIC PROMOTER