Title:
CANCER ANTIGEN PEPTIDE ORIGINATING IN WT1
Document Type and Number:
WIPO Patent Application WO/2005/095598
Kind Code:
A1
Abstract:
It is intended to provide a novel cancer vaccine. Namely, an HLA-A26-binding cancer antigen peptide originating in WT1; a polynucleotide encoding this peptide; a CTL inducer containing the above polypeptide or polynucleotide; and a cancer vaccine containing the above polypeptide or polynucleotide.
Inventors:
SUGIYAMA HARUO (JP)
Application Number:
PCT/JP2005/006113
Publication Date:
October 13, 2005
Filing Date:
March 30, 2005
Export Citation:
Assignee:
SUGIYAMA HARUO (JP)
International Classes:
A61K35/12; A61K35/76; A61K35/761; A61K35/763; A61K35/768; A61K38/00; A61K39/00; A61P35/00; C07K7/06; C07K14/47; C07K14/82; C07K16/30; C07K16/32; C12N1/15; C12N1/19; C12N1/21; C12N5/07; C12N5/09; C12N5/10; C12N15/09; C12P21/02; C12P21/08; G01N33/53; G01N33/569; G01N33/574; A61K48/00; (IPC1-7): C12N15/09; A61K35/12; A61K38/00; A61K39/00; A61K48/00; A61P35/00; C07K14/82; C07K16/32; C12N5/06; C12N5/10; C12P21/02; G01N33/53; G01N33/574
Domestic Patent References:
| WO2000018795A2 | 2000-04-06 |
Foreign References:
| JP2002525099A | 2002-08-13 |
Other References:
ZINSZNER H. ET AL: "Nucleotide sequence of the HLA-A26 class I gene: identification of specific residues and molecular mapping of public HLA class I epitopes", HUM. IMMUNOL., vol. 27, 1990, pages 155 - 166, XP002995884
BELLANTUONO I. ET AL: "Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL", BLOOD, vol. 100, no. 10, 2002, pages 3835 - 3837, XP002995885
GAO L. ET AL: "Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1", BLOOD, vol. 95, no. 7, 2000, pages 2198 - 2203, XP002337253
"Nen 3 Gatsu 1 Nichi", FUNAKOSHI NEWS, no. 2004, 1 March 2004 (2004-03-01), pages 1 - 13, XP002995886
DAL PORTO J. ET AL: "A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6671 - 6675, XP002039180
"Peptide Synthesis", vol. 14, 1991, HIROKAWA-SYOTEN
"Peptide Synthesis", 1966, INTERSCIENCE
"The Proteins", vol. 2, 1976, ACADEMIC PRESS INC.
"Peptide Synthesis", 1975, MARUZEN, INC.
"Peptide-Gosei no Kiso to Jikken", 1985, MARUZEN, INC.
"Peptide Synthesis", vol. 14, 1991, HIROKAWA-SYOTEN, article "Iyakuhin no Kaihatsu"
TISSUE ANTIGEN, vol. 61, 2003, pages 136
JOURNAL OF IMMUNOLOGY, vol. 161, 1998, pages 3186 - 3194
IMMUNITY., vol. 1, 1994, pages 751
JOURNAL OF IMMUNOLOGY, vol. 162, 1999, pages 3915 - 3925
CLINICAL CANCER RES., vol. 7, 2001, pages 3012 - 3024
INT. J. HEMATOL, vol. 76, 2002, pages 127
INT. J. HEMATOL, vol. 78, 2003, pages 56
T. MANIATIS ET AL.: "Molecular Cloning", 1983, CSH LABORATORY
DM. GLOVER: "DNA Cloning", 1985, IRL PRESS
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS
"Antibodies; A Laboratory Manual", 1989, COLD SPRING HARBER LABORATORY PRESS
CANCER IMMUNOL.IMMUNOTHER., vol. 46, 1998, pages 82
J. IMMUNOL., vol. 158, pages 1796
CANCER RES., vol. 59, 1999, pages L184
CANCER RES., vol. 56, 1996, pages 5672
J. IMMUNOL., vol. 161, 1998, pages 5607
J. EXP. MED., vol. 184, 1996, pages 465
JOUMAL OF EXPERIMENTAL MEDICINE, vol. 190, 1999, pages 1669
CLIN. MICROBIOL. REV., vol. 7, 1994, pages 277 - 289
NIKKEI-SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN-YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN-IGAKU-ZOKAN, vol. 12, no. 15, 1994
JIKKENN-IGAKU-ZOKAN, vol. 12, no. 15, 1994
CANCER IMMUNOL. IMMUNOTHER., vol. 46, 1998, pages 82
J. IMMUNOL., vol. 158, 1997, pages 1796
CANCER RES., vol. 59, 1999, pages 1184
J. NATL. CANCER. INST., vol. 86, 1994, pages 1159
J. EXP. MED., vol. 185, 1997, pages 453
IMMUNOGENETICS, vol. 41, 1995, pages 178
J. IMMUNOL., vol. 155, 1995, pages 4749
See also references of EP 1731605A4
BELLANTUONO I. ET AL: "Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL", BLOOD, vol. 100, no. 10, 2002, pages 3835 - 3837, XP002995885
GAO L. ET AL: "Selective elimination of leukemic CD34(+) progenitor cells by cytotoxic T lymphocytes specific for WT1", BLOOD, vol. 95, no. 7, 2000, pages 2198 - 2203, XP002337253
"Nen 3 Gatsu 1 Nichi", FUNAKOSHI NEWS, no. 2004, 1 March 2004 (2004-03-01), pages 1 - 13, XP002995886
DAL PORTO J. ET AL: "A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations", PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6671 - 6675, XP002039180
"Peptide Synthesis", vol. 14, 1991, HIROKAWA-SYOTEN
"Peptide Synthesis", 1966, INTERSCIENCE
"The Proteins", vol. 2, 1976, ACADEMIC PRESS INC.
"Peptide Synthesis", 1975, MARUZEN, INC.
"Peptide-Gosei no Kiso to Jikken", 1985, MARUZEN, INC.
"Peptide Synthesis", vol. 14, 1991, HIROKAWA-SYOTEN, article "Iyakuhin no Kaihatsu"
TISSUE ANTIGEN, vol. 61, 2003, pages 136
JOURNAL OF IMMUNOLOGY, vol. 161, 1998, pages 3186 - 3194
IMMUNITY., vol. 1, 1994, pages 751
JOURNAL OF IMMUNOLOGY, vol. 162, 1999, pages 3915 - 3925
CLINICAL CANCER RES., vol. 7, 2001, pages 3012 - 3024
INT. J. HEMATOL, vol. 76, 2002, pages 127
INT. J. HEMATOL, vol. 78, 2003, pages 56
T. MANIATIS ET AL.: "Molecular Cloning", 1983, CSH LABORATORY
DM. GLOVER: "DNA Cloning", 1985, IRL PRESS
"Current protocols in Molecular Biology", 1987, JOHN WILEY AND SONS
"Antibodies; A Laboratory Manual", 1989, COLD SPRING HARBER LABORATORY PRESS
CANCER IMMUNOL.IMMUNOTHER., vol. 46, 1998, pages 82
J. IMMUNOL., vol. 158, pages 1796
CANCER RES., vol. 59, 1999, pages L184
CANCER RES., vol. 56, 1996, pages 5672
J. IMMUNOL., vol. 161, 1998, pages 5607
J. EXP. MED., vol. 184, 1996, pages 465
JOUMAL OF EXPERIMENTAL MEDICINE, vol. 190, 1999, pages 1669
CLIN. MICROBIOL. REV., vol. 7, 1994, pages 277 - 289
NIKKEI-SCIENCE, April 1994 (1994-04-01), pages 20 - 45
GEKKAN-YAKUJI, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN-IGAKU-ZOKAN, vol. 12, no. 15, 1994
JIKKENN-IGAKU-ZOKAN, vol. 12, no. 15, 1994
CANCER IMMUNOL. IMMUNOTHER., vol. 46, 1998, pages 82
J. IMMUNOL., vol. 158, 1997, pages 1796
CANCER RES., vol. 59, 1999, pages 1184
J. NATL. CANCER. INST., vol. 86, 1994, pages 1159
J. EXP. MED., vol. 185, 1997, pages 453
IMMUNOGENETICS, vol. 41, 1995, pages 178
J. IMMUNOL., vol. 155, 1995, pages 4749
See also references of EP 1731605A4
Attorney, Agent or Firm:
Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
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