CARBOXYLIC ACID DERIVATIVE

WIPO Patent Application WO/2003/055847

A1

A compound which is useful as a VEGF receptor antagonist and has excellent properties. It is a carboxylic acid derivative represented by the formula (1) [wherein ring A represents a benzene ring, naphthalane ring, etc.; W represents C_1-5 alkylene; Z represents a single bond or phenylene; R¹ and R² are the same or different and each represents hydrogen, halogeno, C_1-5 alkyl, or C_1-10 alkoxy; R³ represents hydrogen, halogeno, C_1-12 alkyl, C_2-5 alkynyl, trifluoromethyl, acetynyl, cyano, nitro, -CH₂-R⁶, -Y-R¹¹, etc.; R⁴ represents a group represented by the formula (2) and R⁵ represents hydrogen or C_1-5 alkyl] or a pharmaceutically acceptable salt of the derivative.

SAITO SHUJI (JP)
SUGA YOICHIRO (JP)
SATO MASAKAZU (JP)
SHIBUYA MASABUMI (JP)

PCT/JP2002/013692

July 10, 2003

December 26, 2002

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TAISHO PHARMACEUTICAL CO LTD (JP)
SAITO SHUJI (JP)
SUGA YOICHIRO (JP)
SATO MASAKAZU (JP)
SHIBUYA MASABUMI (JP)

A61K31/198; A61K31/343; A61K31/352; A61K31/381; A61K31/40; A61K31/403; A61K31/42; A61K31/421; A61K31/4245; A61K31/426; A61K31/428; A61K31/4453; A61K31/5375; A61P3/00; A61P9/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07C235/38; C07C255/60; C07C311/46; C07C317/40; C07C323/41; C07D209/76; C07D261/14; C07D263/32; C07D271/10; C07D277/28; C07D277/38; C07D277/42; C07D277/62; C07D295/26; C07D307/91; C07D311/14; C07D333/34; (IPC1-7): C07C235/38; C07C255/60; C07C311/29; C07C317/32; C07C323/41; C07D209/48; C07D209/76; C07D261/14; C07D263/32; C07D271/10; C07D277/28; C07D277/42; C07D277/38; C07D295/22; C07D307/91; C07D311/14; C07D333/34

WO2001002344A1

2001-01-11

EP0262399A2

1988-04-06

Kitagawa, Tomizo (LTD. Intellectual Property Division 24-1, Takata 3-chom, Toshima-ku Tokyo, JP)

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