Title:
CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2002/092068
Kind Code:
A1
Abstract:
Compounds represented by the following general formula (I), prodrugs thereof, salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of having an EDG−1 agonism, the compounds of the general formula (I) are useful in preventing and&sol or treating arteriosclerosis obliterans, thromboangiitis obliterans, Buerger’s disease, peripheral arterial disease of diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, brain infarction, myocardial infarction, edematous diseases, arteriosclerosis, hemorrhoid, anal fissure, varicosity such as anal fistula, dissecting aneurysm, angina, DIC, pleuritis, congestive heart failure, multiorgan failure, bedsore, ambustion, ulcerative colitis, Crohn’s disease, heart transplantation, kidney transplantation, skin transplantation, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, cirrhosis, chronic renal failure or glomerular sclerosis.
Inventors:
SEKO TAKUYA (JP)
TERAKADO MASAHIKO (JP)
KOHNO HIROSHI (JP)
TAKAHASHI SHINYA (JP)
TERAKADO MASAHIKO (JP)
KOHNO HIROSHI (JP)
TAKAHASHI SHINYA (JP)
Application Number:
PCT/JP2002/004520
Publication Date:
November 21, 2002
Filing Date:
May 09, 2002
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
SEKO TAKUYA (JP)
TERAKADO MASAHIKO (JP)
KOHNO HIROSHI (JP)
TAKAHASHI SHINYA (JP)
SEKO TAKUYA (JP)
TERAKADO MASAHIKO (JP)
KOHNO HIROSHI (JP)
TAKAHASHI SHINYA (JP)
International Classes:
A61K31/166; A61K31/167; A61K31/192; A61K31/194; A61K31/196; A61K31/216; A61K31/343; A61K31/381; A61K31/402; A61K31/4184; A61K31/44; A61K31/4402; A61K31/4409; A61K31/5375; A61P1/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/10; A61P27/02; A61P29/00; A61P31/04; A61P43/00; C07C59/68; C07C229/14; C07C229/60; C07C229/62; C07C233/17; C07C233/51; C07C233/73; C07C235/34; C07C235/38; C07C235/66; C07C237/20; C07C237/30; C07C237/32; C07C237/42; C07C311/17; C07C323/62; C07C323/63; C07D213/30; C07D213/40; C07D213/79; C07D213/80; C07D213/82; C07D235/12; C07D295/155; C07D307/60; C07D333/16; (IPC1-7): A61K31/166; A61K31/167; A61K31/192; A61K31/194; A61K31/196; A61K31/216; A61K31/343; A61K31/381; A61K31/402; A61K31/4184; A61K31/44; A61K31/4402; A61K31/4409; A61K31/5375; C07C235/38; C07C237/30; C07C237/32; C07C233/51; C07C235/66; C07C233/17; C07C229/62; C07C229/14; C07C323/63; C07C311/17; A61P1/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/10; A61P27/02; A61P29/00; A61P31/04; A61P43/00; C07D213/30; C07D213/40; C07D213/79; C07D213/81; C07D213/82; C07D235/12; C07D265/30; C07D295/14; C07D307/89; C07D333/16
Foreign References:
| EP0791576A2 | 1997-08-27 | |||
| JPH02218654A | 1990-08-31 |
Other References:
MEYER ZU HERINGDORF D. ET AL.: "Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors", EUR. J. PHARMACOL., vol. 414, March 2001 (2001-03-01), pages 145 - 154, XP002956636
SATO K. ET AL.: "Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells", BRAIN. RES. MOL. BRAIN. RES., vol. 85, 2000, pages 151 - 160, XP002956637
See also references of EP 1391199A4
SATO K. ET AL.: "Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells", BRAIN. RES. MOL. BRAIN. RES., vol. 85, 2000, pages 151 - 160, XP002956637
See also references of EP 1391199A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No. 2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
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