Title:
CATIONIC LIPID HAVING IMPROVED INTRACELLULAR KINETICS
Document Type and Number:
WIPO Patent Application WO/2013/073480
Kind Code:
A1
Abstract:
Provided is a cationic lipid with which it is possible to achieve high intracellular expression efficiency when used as a nucleic acid delivery carrier. The lipid is a compound represented by formula (1) (where Xa and Xb are, independently, X1 or X2; s is 1 or 2; R4 is a C1-6 alkyl group, na and nb are, independently, 0 or 1; R1a and R1b are, independently, a C1-6 alkylene group; R2a and R2b are, independently, a C1-6 alkylene group; Ya and Yb are, independently, an ester bond, an amide bond, a carbamate bond, an ether bond, or a urea bond; and R3a and R3b are, independently, a sterol residue, a fat-soluble vitamin residue, or a C12-22 aliphatic hydrocarbon group).
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Inventors:
TANGE KOTA (JP)
ARAI MASAYA (JP)
KUBO KAZUHIRO (JP)
AKITA HIDETAKA (JP)
HARASHIMA HIDEYOSHI (JP)
HATAKEYAMA HIROTO (JP)
ISHIBA RYOHEI (JP)
UKAWA MASAMI (JP)
TANAKA HIROKI (JP)
ARAI MASAYA (JP)
KUBO KAZUHIRO (JP)
AKITA HIDETAKA (JP)
HARASHIMA HIDEYOSHI (JP)
HATAKEYAMA HIROTO (JP)
ISHIBA RYOHEI (JP)
UKAWA MASAMI (JP)
TANAKA HIROKI (JP)
Application Number:
PCT/JP2012/079160
Publication Date:
May 23, 2013
Filing Date:
November 09, 2012
Export Citation:
Assignee:
NOF CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07C323/25; A61K47/20; A61K47/44; A61K48/00
Domestic Patent References:
WO1999058152A1 | 1999-11-18 | |||
WO2008045486A2 | 2008-04-17 | |||
WO1999058152A1 | 1999-11-18 | |||
WO2010054405A1 | 2010-05-14 | |||
WO2005032593A1 | 2005-04-14 | |||
WO2008105178A1 | 2008-09-04 | |||
WO2011132713A1 | 2011-10-27 |
Foreign References:
DE2521898A1 | 1975-12-04 | |||
JP2011121966A | 2011-06-23 |
Other References:
See also references of EP 2781507A4
BIOMATERIALS, vol. 29, no. 24-25, 2008, pages 3477 - 96
GENE THERAPY, vol. 6, 1999, pages 271 - 281
MOLECULAR THERAPY, vol. 13, no. 4, 2006, pages 786 - 794
UKAWA ET AL., BIOMATERIALS, vol. 31, no. 24, 2010, pages 6355 - 6362
KHALIL ET AL., J CONTROL RELEASE., vol. 156, no. 3, 2011, pages 374 - 80
KHALIL ET AL., J CONTROL RELEASE., vol. 156, no. 3, pages 374 - 80
SHIMIZU K ET AL., J BIOSCI BIOENG, vol. 112, no. 5, pages 508 - 10
AKINC ET AL., MOLECULAR THERAPY, vol. 17, no. 5, 2009, pages 872 - 879
BIOMATERIALS, vol. 29, no. 24-25, 2008, pages 3477 - 96
GENE THERAPY, vol. 6, 1999, pages 271 - 281
MOLECULAR THERAPY, vol. 13, no. 4, 2006, pages 786 - 794
UKAWA ET AL., BIOMATERIALS, vol. 31, no. 24, 2010, pages 6355 - 6362
KHALIL ET AL., J CONTROL RELEASE., vol. 156, no. 3, 2011, pages 374 - 80
KHALIL ET AL., J CONTROL RELEASE., vol. 156, no. 3, pages 374 - 80
SHIMIZU K ET AL., J BIOSCI BIOENG, vol. 112, no. 5, pages 508 - 10
AKINC ET AL., MOLECULAR THERAPY, vol. 17, no. 5, 2009, pages 872 - 879
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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