CATIONIC LIPID HAVING IMPROVED INTRACELLULAR KINETICS

Title:

CATIONIC LIPID HAVING IMPROVED INTRACELLULAR KINETICS

Document Type and Number:

WIPO Patent Application WO/2013/073480

Kind Code:

A9

Abstract:

Provided is a cationic lipid with which it is possible to achieve high intracellular expression efficiency when used as a nucleic acid delivery carrier. The lipid is a compound represented by formula (1) (where Xa and Xb are, independently, X1 or X2; s is 1 or 2; R4 is a C1-6 alkyl group, na and nb are, independently, 0 or 1; R1a and R1b are, independently, a C1-6 alkylene group; R2a and R2b are, independently, a C1-6 alkylene group; Ya and Yb are, independently, an ester bond, an amide bond, a carbamate bond, an ether bond, or a urea bond; and R3a and R3b are, independently, a sterol residue, a fat-soluble vitamin residue, or a C12-22 aliphatic hydrocarbon group).

More Like This:

JPS63185945	DERIVATIVE CONTAINING AMINO GROUP OF 1,3-DI-SUBSTITUTED 2-PROPANOL, MANUFACTURE AND USE
JP5086635	Antibacterial agent

Inventors:

TANGE KOTA (JP)
ARAI MASAYA (JP)
KUBO KAZUHIRO (JP)
AKITA HIDETAKA (JP)
HARASHIMA HIDEYOSHI (JP)
HATAKEYAMA HIROTO (JP)
ISHIBA RYOHEI (JP)
UKAWA MASAMI (JP)
TANAKA HIROKI (JP)

Application Number:

PCT/JP2012/079160

Publication Date:

July 18, 2013

Filing Date:

November 09, 2012

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NOF CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)

International Classes:

C07C323/25; A61K47/20; A61K47/44; A61K48/00

Attorney, Agent or Firm:

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

Download PDF:

View/Download PDF PDF Help

Claims:

Previous Patent: MOBILE COMMUNICATION METHOD, RADIO BASE STATION AND MOBILE STATION

Next Patent: HOLE PLUG