Title:
CD137 AS A PROLIFERATION FACTOR FOR HEMATOPOIETIC STEM CELLS
Document Type and Number:
WIPO Patent Application WO2003031474
Kind Code:
A3
Abstract:
The invention provides the CD137 molecule or a functional analogue thereof, for use in stimulating hematopoiesis. The invention further provides a method of treatment of a disorder characterized by insufficient numbers of cells of the hematopoietic system, including not limited to T cells, B cells, granulocytes, macrophages, mesenchymal cells, osteoclasts and multipotent adult progenitor cells, comprising the application of CD137 or a functional analogue thereof.
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Inventors:
SCHWARZ HERBERT (GB)
Application Number:
PCT/EP2002/011101
Publication Date:
October 16, 2003
Filing Date:
October 03, 2002
Export Citation:
Assignee:
SCHWARZ HERBERT (GB)
International Classes:
A61K38/17; C07K14/705; (IPC1-7): C07K14/705; A61K38/17
Domestic Patent References:
| WO1999044629A2 | 1999-09-10 |
Foreign References:
| CA2108401A1 | 1995-03-28 | |||
| US20010014465A1 | 2001-08-16 |
Other References:
LANGSTEIN J ET AL: "Identification of CD137 as a potent monocyte survival factor", JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL, US, vol. 65, June 1999 (1999-06-01), pages 829 - 833, XP002122045, ISSN: 0741-5400
LANGSTEIN J ET AL: "CD137 ( ILA /4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 160, no. 5, 1 March 1998 (1998-03-01), pages 2488 - 2494, XP002122043, ISSN: 0022-1767
LANGSTEIN J ET AL: "CD137 INDUCES PROLIFERATION AND ENDOMITOSIS IN MONOCYTES", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 9, 1999, pages 3161 - 3168, XP000886912, ISSN: 0006-4971
KWON B. ET AL.: "4.1BB:still in the midst of darkness.", MOL. CELLS, vol. 10, no. 2, 2000, pages 119 - 126, XP002230067
LANGSTEIN J ET AL: "CD137 ( ILA /4-1BB), a member of the TNF receptor family, induces monocyte activation via bidirectional signaling", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 160, no. 5, 1 March 1998 (1998-03-01), pages 2488 - 2494, XP002122043, ISSN: 0022-1767
LANGSTEIN J ET AL: "CD137 INDUCES PROLIFERATION AND ENDOMITOSIS IN MONOCYTES", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 9, 1999, pages 3161 - 3168, XP000886912, ISSN: 0006-4971
KWON B. ET AL.: "4.1BB:still in the midst of darkness.", MOL. CELLS, vol. 10, no. 2, 2000, pages 119 - 126, XP002230067
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