Title:
CD47/HUMANIZED CD47 ANTIBODY OR ANTIGEN BINDING FRAGMENT OR IMMUNOLOGICALLY ACTIVE FRAGMENT THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/190441
Kind Code:
A1
Abstract:
Provided is a CD47/humanized CD47 antibody or an antigen binding fragment or an immunologically active fragment thereof, which is capable of blocking the binding of CD47 and SIRPα, and activating and mediating the phagocytic activity of macrophages on tumor cells. Further disclosed are a corresponding nucleic acid, an expression vector, a host cell and a pharmaceutical composition that can be used in the preparation of a drug for treating CD47-mediated diseases.
Inventors:
ZHANG CHONGQIAN (CN)
ZHANG NAN (CN)
LI HONGXIA (CN)
ZONG CHAO (CN)
WANG LEI (CN)
HUANG SUPING (CN)
TANG CHUN (CN)
ZHANG XIAOXIA (CN)
PENG JIRONG (CN)
ZHANG DON (CN)
ZHANG NAN (CN)
LI HONGXIA (CN)
ZONG CHAO (CN)
WANG LEI (CN)
HUANG SUPING (CN)
TANG CHUN (CN)
ZHANG XIAOXIA (CN)
PENG JIRONG (CN)
ZHANG DON (CN)
Application Number:
PCT/CN2021/082047
Publication Date:
September 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
BETAPHARMA SUZHOU LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; C12N5/10; C12N15/13; C12N15/85
Foreign References:
| CN110066336A | 2019-07-30 | |||
| CN110872350A | 2020-03-10 | |||
| CN108779179A | 2018-11-09 | |||
| CN105102479A | 2015-11-25 | |||
| CN111454359A | 2020-07-28 |
Attorney, Agent or Firm:
SU ZHOU ZHONG HE INTELLECTUAL PROPERTY FIRM (CN)
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