Title:
CDK9 INHIBITOR PRODRUG AND LIPOSOME INCLUDING THE SAME
Document Type and Number:
WIPO Patent Application WO/2021/172359
Kind Code:
A1
Abstract:
Provided is a novel CDK9 inhibitor prodrug and a liposome that includes the same.
The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a liposome that includes the same. [In the formula, A1, A2 and A3 are the same or different, and are each independently -C(=O)E, -CO2E, or a hydrogen atom or the like; E is a group represented by formula (E); the * in the formula indicates a bonding location.
X is an optionally-substituted 3- to 12-membered monocyclic or polycyclic divalent heterocyclic group or the like; Y is a single bond or the like; and Z is an optionally-substituted 5- to 10-membered heteroaryl group or the like.]
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Inventors:
SAWAYAMA YUSUKE (JP)
MATSUOKA MAKOTO (JP)
KAMIOKA SEIJI (JP)
BAN HITOSHI (JP)
SHIMADA NAOAKI (JP)
MATSUOKA MAKOTO (JP)
KAMIOKA SEIJI (JP)
BAN HITOSHI (JP)
SHIMADA NAOAKI (JP)
Application Number:
PCT/JP2021/006873
Publication Date:
September 02, 2021
Filing Date:
February 24, 2021
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K45/00; A61K9/127; A61K31/453; A61K31/4545; A61K31/496; A61K31/506; A61K31/55; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61P35/00; A61P35/02; C07D405/04; C07D405/14; C07D451/02; C07D453/02; C07D471/10
Domestic Patent References:
| WO2018094275A1 | 2018-05-24 | |||
| WO2019224790A2 | 2019-11-28 |
Foreign References:
| US6352996B1 | 2002-03-05 | |||
| CN106866733A | 2017-06-20 | |||
| US20190256548A1 | 2019-08-22 |
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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