Title:
CELL COMPOSITIONS DERIVED FROM DEDIFFERENTIATED REPROGRAMMED CELLS
Document Type and Number:
WIPO Patent Application WO/2010/124142
Kind Code:
A3
Abstract:
Methods and cell culture compositions, in particular, pancreatic cell culture methods and compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as, induced pluripotent stem (iPS) cells.
Inventors:
AGULNICK ALAN (US)
D AMOUR KEVIN ALLEN (US)
D AMOUR KEVIN ALLEN (US)
Application Number:
PCT/US2010/032130
Publication Date:
April 14, 2011
Filing Date:
April 22, 2010
Export Citation:
Assignee:
VIACYTE INC (US)
AGULNICK ALAN (US)
D AMOUR KEVIN ALLEN (US)
AGULNICK ALAN (US)
D AMOUR KEVIN ALLEN (US)
International Classes:
C12N5/074; C07K14/47; C12N5/02
Other References:
ZHANG, D. ET AL.: "Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells.", CELL RESEARCH, vol. 19, 2009, pages 429 - 438, XP055074920, DOI: doi:10.1038/cr.2009.28
HAMMAR, E. ET AL.: "Role of the Rho-ROCK(Rho-Associated Kinase) signaling pathway in the regulation of pancreatic cell function.", ENDOCRINOLOGY, vol. 150, no. 5, 2009, pages 2072 - 2079, XP055089550, DOI: doi:10.1210/en.2008-1135
SOSA-PINEDA, B.: "The gene pax4 is an essential regulator of pancreatic beta-cell development.", MOLECULES AND CELLS, vol. 18, no. 3, 2004, pages 289 - 294
HUANGFU, D. ET AL.: "Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.", NATURE BIOTECHNOLOGY, vol. 26, no. 11, 2008, pages 1269 - 1275, XP002534948
SEGEV, H. ET AL.: "Differentiation of human embryonic stem cells into insulin -producing clusters.", STEM CELLS, vol. 22, 2004, pages 265 - 274, XP009038283, DOI: doi:10.1634/stemcells.22-3-265
HAMMAR, E. ET AL.: "Role of the Rho-ROCK(Rho-Associated Kinase) signaling pathway in the regulation of pancreatic cell function.", ENDOCRINOLOGY, vol. 150, no. 5, 2009, pages 2072 - 2079, XP055089550, DOI: doi:10.1210/en.2008-1135
SOSA-PINEDA, B.: "The gene pax4 is an essential regulator of pancreatic beta-cell development.", MOLECULES AND CELLS, vol. 18, no. 3, 2004, pages 289 - 294
HUANGFU, D. ET AL.: "Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2.", NATURE BIOTECHNOLOGY, vol. 26, no. 11, 2008, pages 1269 - 1275, XP002534948
SEGEV, H. ET AL.: "Differentiation of human embryonic stem cells into insulin -producing clusters.", STEM CELLS, vol. 22, 2004, pages 265 - 274, XP009038283, DOI: doi:10.1634/stemcells.22-3-265
Attorney, Agent or Firm:
MALLON, Joseph, J. (2040 Main Street Fourteenth Floo, Irvine CA, US)
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