Title:
CHARACTERISTIC POLYPEPTIDE COMPOSITION FOR DIAGNOSING COVID-19
Document Type and Number:
WIPO Patent Application WO/2022/166486
Kind Code:
A1
Abstract:
Provided is a characteristic polypeptide composition for detecting COVID-19, comprising 29 characteristic polypeptides having specific mass-to-charge ratios. By analyzing the expression of the characteristic polypeptides, whether the sample is a COVID-19 patient can be determined. Also provided is use of a mass spectrum model prepared according to the characteristic polypeptide composition in a product for diagnosing COVID-19, etc. For the first time, an approach of finding a plurality of characteristic protein combinations having differences according to COVID-19 patients/normal people, pulmonary tuberculosis patients, and controls having COVID-19 type symptoms is proposed, a conventional search approach for finding the characteristic polypeptides only from the normal people and the COVID-19 patients is broken through, infection of false positive results having symptoms similar to those of COVID-19 is effectively avoided, the advantages of simple operation, low detection cost, and high accuracy are achieved, and the present invention is expected to be used for large-scale screening of COVID-19.
Inventors:
LIAO PU (CN)
SUN WEI (CN)
QIAO LIANG (CN)
LU QIAN (CN)
MA QINGWEI (CN)
SUN WEI (CN)
QIAO LIANG (CN)
LU QIAN (CN)
MA QINGWEI (CN)
Application Number:
PCT/CN2021/142821
Publication Date:
August 11, 2022
Filing Date:
December 30, 2021
Export Citation:
Assignee:
BEIJING YIXINBOCHUANG BIOTECHNOLOGY CO LTD (CN)
International Classes:
G01N33/68; G01N27/64; G01N33/72
Foreign References:
| CN111830120A | 2020-10-27 | |||
| CN110632326A | 2019-12-31 | |||
| CN110658252A | 2020-01-07 | |||
| CN105572355A | 2016-05-11 | |||
| CN111366735A | 2020-07-03 | |||
| CN111394513A | 2020-07-10 |
Other References:
ILES, R.K. ET AL.: "Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2: Rational Design and Multi-Disciplinary Team Work", DIAGNOSTICS, vol. 10, 24 September 2020 (2020-09-24), XP055768787, DOI: 10.3390/diagnostics10100746
NACHTIGALL, F.M. ET AL.: "Detection of SARS-CoV-2 in nasal swabs using MALDI-MS", NATURE BIOTECHNOLOGY, vol. 38, 30 July 2020 (2020-07-30), XP037524000, DOI: 10.1038/s41587-020-0644-7
NACHTIGALL, F.M. ET AL.: "Detection of SARS-CoV-2 in nasal swabs using MALDI-MS", NATURE BIOTECHNOLOGY, vol. 38, 30 July 2020 (2020-07-30), XP037524000, DOI: 10.1038/s41587-020-0644-7
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