Title:
CHEMICALLY MODIFIED INTERFERON
Document Type and Number:
WIPO Patent Application WO1996021468
Kind Code:
A3
Abstract:
The present invention relates to chemically modified consensus interferon having one or more glycosyl ligand(s) conjugated to consensus interferon. Pharmaceutical compositions containing such analog, and methods of treatment using the compositions of the invention are also provided.
Inventors:
COLLINS DAVID
LIU JENNIFER LIN-CHUN
LIU JENNIFER LIN-CHUN
Application Number:
PCT/US1996/000323
Publication Date:
September 12, 1996
Filing Date:
January 11, 1996
Export Citation:
Assignee:
AMGEN INC (US)
International Classes:
A61K38/21; A61K47/48; A61P1/16; A61P31/12; A61P43/00; C07K14/555; C07K14/56; A61K38/00; (IPC1-7): A61K47/48; A61K38/21; C07K14/56
Domestic Patent References:
| WO1993021229A1 | 1993-10-28 | |||
| WO1992022310A1 | 1992-12-23 |
Foreign References:
| EP0589378A2 | 1994-03-30 |
Other References:
CHEMICAL ABSTRACTS, vol. 122, no. 12, 20 March 1995, Columbus, Ohio, US; abstract no. 142499f, ZHONG YUGUO ET AL: "Liver-targetable galactosyl interferon conjugate for diagnosis and treatment of liver diseases" page 660; column r; XP002006625
MIKIO KATAOKA ET AL: "Synthetic neoglycoproteins: a class of reagents for detection of sugar-recognizing substances", THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, vol. 32, no. 10, 1984, pages 1091 - 1098, XP000572708
R.W. NIVEN ET AL: "Systemic absorption and activity of recombunant consensus interferons after intratracheal instillation and aerosol administration", PHARMACEUTICAL RESEARCH, vol. 12, no. 12, December 1995 (1995-12-01), pages 1889 - 1895, XP002006623
J.E. LABDON ET AL: "Some species of human lLeukocyte Interferon are glycosylated", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 232, no. 1, July 1984 (1984-07-01), pages 422 - 426, XP002006624
MIKIO KATAOKA ET AL: "Synthetic neoglycoproteins: a class of reagents for detection of sugar-recognizing substances", THE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY, vol. 32, no. 10, 1984, pages 1091 - 1098, XP000572708
R.W. NIVEN ET AL: "Systemic absorption and activity of recombunant consensus interferons after intratracheal instillation and aerosol administration", PHARMACEUTICAL RESEARCH, vol. 12, no. 12, December 1995 (1995-12-01), pages 1889 - 1895, XP002006623
J.E. LABDON ET AL: "Some species of human lLeukocyte Interferon are glycosylated", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 232, no. 1, July 1984 (1984-07-01), pages 422 - 426, XP002006624
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