Title:
CHIMERIC, HUMANIZED AND SINGLE CHAIN ANTIBODIES TO ALPHA-2-ANTIPLASMIN
Document Type and Number:
WIPO Patent Application WO1998012334
Kind Code:
A3
Abstract:
An immunologic molecule, wherein said immunologic molecule does not compete with monoclonal antibody RWR and is capable of binding to and inhibit both (1) human and nonhuman circulating alpha-2-antiplasmins and (2) human and nonhuman fibrin cross-linked alpha-2-antiplasmins selected from the group consisting of a chimeric antibody, a humanized antibody, and a single chain antibody. The invention further relates to nucleic acid molecules encoding said immunologic molecules. 00000
More Like This:
Inventors:
REED GUY L (US)
HARRIS LINDA (US)
BAJORATH JURGEN (US)
MATSUEDA GARY (US)
HSU MEI-YIN (US)
NOVOTNY JIRI (US)
HARRIS LINDA (US)
BAJORATH JURGEN (US)
MATSUEDA GARY (US)
HSU MEI-YIN (US)
NOVOTNY JIRI (US)
Application Number:
PCT/US1997/016123
Publication Date:
July 23, 1998
Filing Date:
September 19, 1997
Export Citation:
Assignee:
REED GUY L (US)
HARRIS LINDA (US)
BAJORATH JURGEN (US)
MATSUEDA GARY (US)
HSU MEI-YIN (US)
NOVOTNY JIRI (US)
HARRIS LINDA (US)
BAJORATH JURGEN (US)
MATSUEDA GARY (US)
HSU MEI-YIN (US)
NOVOTNY JIRI (US)
International Classes:
G01N33/53; A61K39/395; A61K45/00; A61P7/02; A61P9/10; A61P11/00; C07K16/18; C07K16/38; C07K16/46; C12N5/10; C12N15/09; C12N15/13; C12P21/08; G01N33/86; A61K38/00; C12R1/91; (IPC1-7): C12N15/62; C07K16/38; C07K16/46; C12N5/10; C12N15/13
Domestic Patent References:
| WO1988001649A1 | 1988-03-10 |
Foreign References:
| EP0159025A2 | 1985-10-23 |
Other References:
G. SOE ET AL.: "A rapid latex immunoassay for the detection of plasmin-alpha2-plasmin inhibitor complex. Utilization of two monoclonal antibodies differentially recognizing respective components of the complex.", BLOOD COAGULATION AND FIBRINOLYSIS, vol. 6, no. 3, May 1995 (1995-05-01), OXFORD, GB, pages 249 - 258, XP002062704
Y. SAKATA ET AL.: "Clot lysis induced by a monoclonal antibody against alpha2-plasmin inhibitor.", BLOOD, vol. 74, no. 8, December 1989 (1989-12-01), NEW YORK, NY, USA, pages 2692 - 2697, XP002062668
G. REED ET AL.: "Synergistic fibrinolysis: Combined effects of plasminogen activators and an antibody that inhibits alpha2-antiplasmin.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 87, no. 3, February 1990 (1990-02-01), WASHINGTON, DC, USA, pages 1114 - 1118, XP002062667
P. JONES ET AL.: "Replacing the complementarity-determining regions in a human antibody with those from a mouse.", NATURE, vol. 321, 29 May 1986 (1986-05-29), LONDON, GB, pages 522 - 525, XP002062670
V. OI: "Chimeric antibodies.", BIOTECHNIQUES, vol. 4, no. 3, May 1986 (1986-05-01), NATICK, MA, USA, pages 214 - 221, XP002062669
G. REED: "77 (anti alpha2 antiplasmin)", HYBRIDOMA, vol. 16, no. 4, August 1997 (1997-08-01), NEW YORK, NY, USA, pages 392, XP002062705
G. REED: "Functional characterization of monoclonal antibody inhibitors of alpha2-antiplasmin that accelerate fibrinolysis in different animal plasmas.", HYBRIDOMA, vol. 16, no. 3, June 1997 (1997-06-01), NEW YORK, NY, USA, pages 281 - 286, XP002062706
A. BUTTE ET AL.: "Alpha2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism.", CIRCULATION, vol. 95, no. 7, 1 April 1997 (1997-04-01), NEW YORK, NY, USA, pages 1886 - 1891, XP002062707
Y. SAKATA ET AL.: "Clot lysis induced by a monoclonal antibody against alpha2-plasmin inhibitor.", BLOOD, vol. 74, no. 8, December 1989 (1989-12-01), NEW YORK, NY, USA, pages 2692 - 2697, XP002062668
G. REED ET AL.: "Synergistic fibrinolysis: Combined effects of plasminogen activators and an antibody that inhibits alpha2-antiplasmin.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 87, no. 3, February 1990 (1990-02-01), WASHINGTON, DC, USA, pages 1114 - 1118, XP002062667
P. JONES ET AL.: "Replacing the complementarity-determining regions in a human antibody with those from a mouse.", NATURE, vol. 321, 29 May 1986 (1986-05-29), LONDON, GB, pages 522 - 525, XP002062670
V. OI: "Chimeric antibodies.", BIOTECHNIQUES, vol. 4, no. 3, May 1986 (1986-05-01), NATICK, MA, USA, pages 214 - 221, XP002062669
G. REED: "77 (anti alpha2 antiplasmin)", HYBRIDOMA, vol. 16, no. 4, August 1997 (1997-08-01), NEW YORK, NY, USA, pages 392, XP002062705
G. REED: "Functional characterization of monoclonal antibody inhibitors of alpha2-antiplasmin that accelerate fibrinolysis in different animal plasmas.", HYBRIDOMA, vol. 16, no. 3, June 1997 (1997-06-01), NEW YORK, NY, USA, pages 281 - 286, XP002062706
A. BUTTE ET AL.: "Alpha2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism.", CIRCULATION, vol. 95, no. 7, 1 April 1997 (1997-04-01), NEW YORK, NY, USA, pages 1886 - 1891, XP002062707
Download PDF:
Previous Patent: COMPOSITIONS AND METHODS FOR TREATING INTRACELLULAR DISEASES
Next Patent: ARTIFICIAL CHROMOSOME
Next Patent: ARTIFICIAL CHROMOSOME