Title:
CHIMERIC VACCINE ANTIGENS AGAINST THE AVIAN INFLUENZA VIRUS
Document Type and Number:
WIPO Patent Application WO2007098718
Kind Code:
A8
Abstract:
The present invention describes chimeric vaccine antigens against the avian influenza virus (AIV). Said vaccine antigens are based on viral subunits that are coupled to protein molecules that stimulate not only the cellular but also the humoral immune system. The chimeric antigens may be produced in expression systems that guarantee correct three-dimensional folding of the chimeric molecules that constitute the basis of the present invention. The vaccine compositions that contain said chimeric antigens induce a potent, early immune response both in birds and in vaccinated mammals, stimulating high haemagglutinin-inhibiting antibody titres and a potent specific cellular response against the viral antigen. The chimeric antigens, and also the resulting vaccine compositions, are applicable to the field of human and animal health as vaccines for preventive use.
Inventors:
SANCHEZ RAMOS OLIBERTO (CU)
TOLEDO ALONSO JORGE ROBERTO (CU)
DIAZ ARCHER DAMARYS (CU)
FIGUEROA BAILE NANCY ELENA (CU)
RODRIGUEZ MOLTO MARIA PILAR (CU)
BORROTO NORDELO CARLOS GUILLERMO (CU)
TOLEDO ALONSO JORGE ROBERTO (CU)
DIAZ ARCHER DAMARYS (CU)
FIGUEROA BAILE NANCY ELENA (CU)
RODRIGUEZ MOLTO MARIA PILAR (CU)
BORROTO NORDELO CARLOS GUILLERMO (CU)
Application Number:
PCT/CU2007/000009
Publication Date:
December 18, 2008
Filing Date:
February 28, 2007
Export Citation:
Assignee:
CT INGENIERIA GENETICA BIOTECH (CU)
SANCHEZ RAMOS OLIBERTO (CU)
TOLEDO ALONSO JORGE ROBERTO (CU)
DIAZ ARCHER DAMARYS (CU)
FIGUEROA BAILE NANCY ELENA (CU)
RODRIGUEZ MOLTO MARIA PILAR (CU)
BORROTO NORDELO CARLOS GUILLER (CU)
SANCHEZ RAMOS OLIBERTO (CU)
TOLEDO ALONSO JORGE ROBERTO (CU)
DIAZ ARCHER DAMARYS (CU)
FIGUEROA BAILE NANCY ELENA (CU)
RODRIGUEZ MOLTO MARIA PILAR (CU)
BORROTO NORDELO CARLOS GUILLER (CU)
International Classes:
C07K16/10
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