Title:
COMBINATION THERAPIES FOR ERADICATING FLAVIVIRUS INFECTIONS IN SUBJECTS
Document Type and Number:
WIPO Patent Application WO/2018/071623
Kind Code:
A3
Abstract:
Compositions that specifically cleave target sequences in Flavivirus, for example Zika virus include a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) associated endonuclease, a guide RNA sequence complementary to a target sequence in a Zika virus and an anti- viral agent. These compositions are administered to a subject for treating an infection or at risk for contracting a Zika virus infection.
Inventors:
KHALILI KAMEL (US)
SARIYER ILKER (US)
WOLLEBO HASSEN (US)
SARIYER ILKER (US)
WOLLEBO HASSEN (US)
Application Number:
PCT/US2017/056267
Publication Date:
June 14, 2018
Filing Date:
October 12, 2017
Export Citation:
Assignee:
UNIV TEMPLE (US)
International Classes:
C12N9/22; C07K14/18; C12N15/113
Domestic Patent References:
| WO2015048577A2 | 2015-04-02 | |||
| WO2016123243A1 | 2016-08-04 |
Other References:
DATABASE Nucleotide [O] 30 September 2009 (2009-09-30), ANONYMOUS: "Dengue virus 2 isolate DENV-2/CO/BID-V3358/1986, complete genome", XP055510848, retrieved from NCBI Database accession no. GQ868592.1
DATABASE Nucleotide [O] 22 February 2016 (2016-02-22), "Zika virus strain MR 766 polyprotein gene , complete cds", XP055510851, retrieved from NCBI Database accession no. KU720415.1.
DATABASE Nucleotide [O] 22 February 2016 (2016-02-22), "Zika virus strain MR 766 polyprotein gene , complete cds", XP055510851, retrieved from NCBI Database accession no. KU720415.1.
Attorney, Agent or Firm:
ZACHARIADES, Nicholas, A. et al. (US)
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