Title:
COMPOSITION FOR AMELIORATING INFLAMMATION ASSOCIATED WITH CHRONIC HYPOXIA
Document Type and Number:
WIPO Patent Application WO/2024/090329
Kind Code:
A1
Abstract:
The present inventors have found that a pyridoxal synthetic enzyme Pyridoxamine-5'-phosphate oxidase (PNPO) acts as an oxygen sensing mechanism for a novel pathway that is independent from an HIF pathway in chronic hypoxia. A pharmaceutical composition containing, as an active ingredient, pyridoxal produced with PNPO or a phosphate of the pyridoxal is effective as a supplement or a pharmaceutical composition for improving the exacerbation of an inflammatory reaction by chronic hypoxia. A product produced by an enzymatic reaction in which pyridoxal or pyridoxal phosphate is involved as a coenzyme, more specifically a supersulfide or a ferrous compound, is also effective as a supplement or a pharmaceutical composition for improving the exacerbation of an inflammatory reaction by chronic hypoxia.
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Inventors:
SEKINE HIROKI (JP)
MOTOHASHI HOZUMI (JP)
MOTOHASHI HOZUMI (JP)
Application Number:
PCT/JP2023/037930
Publication Date:
May 02, 2024
Filing Date:
October 19, 2023
Export Citation:
Assignee:
UNIV TOHOKU (JP)
International Classes:
A61K45/00; A61K31/44; A61K31/675; A61P7/06; A61P9/00; A61P11/00; A61P29/00; A61P43/00
Domestic Patent References:
| WO2021235494A1 | 2021-11-25 | |||
| WO1995031194A1 | 1995-11-23 |
Foreign References:
| CN111679071A | 2020-09-18 |
Other References:
守田匡伸 ほか, 活性硫黄分子によるインフルエンザウイルス肺炎の予防・治療法の開発, 日本生体防御学会学術総会講演抄録集, 2020, vol. 31st, p. 41, (MORITA, Masanobu et al., Reactive sulfur species protection against influenza virus-induced pneumonia), non-official translation (Proceedings of the Annual Meeting of the Japanese Society for Host Defense Research)
SIMIN JIANG: "The role of sulfur compounds in chronic obstructive pulmonary disease", FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 9, 19 October 2022 (2022-10-19), pages 1 - 14, XP093162185, ISSN: 2296-889X, DOI: 10.3389/fmolb.2022.928287
関根弘樹, 慢性低酸素時の炎症反応促進におけるリソソーム活性低下の分子機構, 第94回日本生化学会大会 講演要旨集, 2021, abstract no. 1S11e-04, (SEKINE, Hiroki), non-official translation (Molecular mechanism of decreased lysosomal activity in promoting inflammatory response during chronic hypoxia, Proceedings of 94th Annual Meeting of the Japanese Biochemical Society)
IDA TOMOAKI; NISHIMURA AKIRA; MORITA MASANOBU; MOTOHASHI HOZUMI; AKAIKE TAKAAKI: "Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 112, 2017, US , pages 189 - 190, XP085287117, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.10.297
SIMIN JIANG: "The role of sulfur compounds in chronic obstructive pulmonary disease", FRONTIERS IN MOLECULAR BIOSCIENCES, vol. 9, 19 October 2022 (2022-10-19), pages 1 - 14, XP093162185, ISSN: 2296-889X, DOI: 10.3389/fmolb.2022.928287
関根弘樹, 慢性低酸素時の炎症反応促進におけるリソソーム活性低下の分子機構, 第94回日本生化学会大会 講演要旨集, 2021, abstract no. 1S11e-04, (SEKINE, Hiroki), non-official translation (Molecular mechanism of decreased lysosomal activity in promoting inflammatory response during chronic hypoxia, Proceedings of 94th Annual Meeting of the Japanese Biochemical Society)
IDA TOMOAKI; NISHIMURA AKIRA; MORITA MASANOBU; MOTOHASHI HOZUMI; AKAIKE TAKAAKI: "Cysteine Hydropersulfide Production Catalyzed by Cysteinyl-tRNA Synthetases", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 112, 2017, US , pages 189 - 190, XP085287117, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.10.297
Attorney, Agent or Firm:
SHIRAKATA Yumiko (JP)
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