Title:
COMPOSITION CONTAINING PENTOSE AND XYLITOL AS ACTIVE INGREDIENTS FOR SUPPRESSING ORAL BACTERIAL ATTACHMENT
Document Type and Number:
WIPO Patent Application WO/2015/105294
Kind Code:
A1
Abstract:
The present invention relates to a composition and an oral product, which contain a pentose and xylitol as active ingredients for suppressing oral bacterial attachment. The oral composition according to the present invention can suppress the inflow autoinducer-2 (AI-2), which is associated with bacterial plaque formation, into bacteria, and thus can reduce the expression of gbpC and dblB, which are genes for promoting bacterial attachment, thereby effectively suppressing plaque formation. In addition, it was verified that the pentose has an effect of inhibiting reaction to xylitol resistance as well as boosting an effect of xylitol, which has been widely used for cavity inhibition. The pentose and xylitol of the present invention are cheap and harmless to the human body and add a flavor, and thus can be favorably used as a food additive.
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Inventors:
HONG SU-HYUNG (KR)
LEE HEON-JIN (KR)
DO AE-JIN (KR)
PARK SANG-BIN (KR)
OH TAE-JUN (KR)
LEE BHUMGEY-DAVID (KR)
LEE HYUN-HO (KR)
LEE MIN-CHAN (KR)
LEE SO-HUI (KR)
HAN SE-YEONG (KR)
LEE HEON-JIN (KR)
DO AE-JIN (KR)
PARK SANG-BIN (KR)
OH TAE-JUN (KR)
LEE BHUMGEY-DAVID (KR)
LEE HYUN-HO (KR)
LEE MIN-CHAN (KR)
LEE SO-HUI (KR)
HAN SE-YEONG (KR)
Application Number:
PCT/KR2014/013005
Publication Date:
July 16, 2015
Filing Date:
December 30, 2014
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACAD (KR)
International Classes:
A61K31/7004; A61K31/70; A61P1/02
Foreign References:
| US4291045A | 1981-09-22 |
Other References:
LEE, S. H. ET AL.: "The cariogenic characters of xylitol-resistant and xylitol-sensitive Streptococcus mutans in biofilm formation with salivary bacteria", ARCHIVES OF ORAL BIOLOGY, vol. 57, no. 6, 2012, pages 697 - 703
LEE, Y. J. ET AL.: "Inhibitory Effect of Pentose on Biofilm Formation by Oral Bacteria", INTERNATIONAL JOURNAL OF ORAL BIOLOGY, vol. 35, no. 4, 2010, pages 203 - 207
JANG, Y. J. ET AL.: "Autoinducer 2 of Fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens", ARCHIVES OF ORAL BIOLOGY, vol. 58, no. 1, 2013, pages 17 - 27
BISWAS, I. ET AL.: "Regulation of gbpC expression in Streptococcus mutans", JOURNAL OF BACTERIOLOGY, vol. 189, no. 18, 2007, pages 6521 - 6531
LEE, H. J. ET AL.: "Synergistic inhibition of Streptococcal biofilm by ribose and xylitol", ARCHIVES OF ORAL BIOLOGY, vol. 60, no. 2, 15 November 2014 (2014-11-15), pages 304 - 312
LEE, Y. J. ET AL.: "Inhibitory Effect of Pentose on Biofilm Formation by Oral Bacteria", INTERNATIONAL JOURNAL OF ORAL BIOLOGY, vol. 35, no. 4, 2010, pages 203 - 207
JANG, Y. J. ET AL.: "Autoinducer 2 of Fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens", ARCHIVES OF ORAL BIOLOGY, vol. 58, no. 1, 2013, pages 17 - 27
BISWAS, I. ET AL.: "Regulation of gbpC expression in Streptococcus mutans", JOURNAL OF BACTERIOLOGY, vol. 189, no. 18, 2007, pages 6521 - 6531
LEE, H. J. ET AL.: "Synergistic inhibition of Streptococcal biofilm by ribose and xylitol", ARCHIVES OF ORAL BIOLOGY, vol. 60, no. 2, 15 November 2014 (2014-11-15), pages 304 - 312
Attorney, Agent or Firm:
LEE, MYOUNG-JIN (KR)
이명진 (KR)
이명진 (KR)
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