Title:
COMPOSITION FOR IMPROVING INTESTINAL BARRIER FUNCTION AND STRENGTHENING INTESTINAL EPITHELIAL TIGHT JUNCTIONS
Document Type and Number:
WIPO Patent Application WO/2024/100755
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a composition for improving the intestinal barrier function and/or strengthening intestinal epithelial tight junctions that contains Lactobacillus plantarum L-137 or a processed product thereof. [Solution] This problem is solved by means of the abovementioned composition.
Inventors:
OHARA TATSUYA (JP)
WATANABE MOTOTSUGU (JP)
NAKAI HIROKO (JP)
NAKAJIMA TSUBASA (JP)
YAMAGUCHI MIKA (JP)
KAWASAKI KENGO (JP)
HIROSE YOSHITAKA (JP)
WATANABE MOTOTSUGU (JP)
NAKAI HIROKO (JP)
NAKAJIMA TSUBASA (JP)
YAMAGUCHI MIKA (JP)
KAWASAKI KENGO (JP)
HIROSE YOSHITAKA (JP)
Application Number:
PCT/JP2022/041496
Publication Date:
May 16, 2024
Filing Date:
November 08, 2022
Export Citation:
Assignee:
HOUSE WELLNESS FOODS CORP (JP)
International Classes:
A23L33/135; A23L31/00; A61K35/747; A61P1/00; A61P3/10; A61P17/00; A61P37/08
Foreign References:
| CN113842400A | 2021-12-28 | |||
| JPH10114667A | 1998-05-06 | |||
| JP2021151988A | 2021-09-30 | |||
| JP2021120359A | 2021-08-19 |
Other References:
RIEKO YOSHITAKE: "Heat-killed Lactobacillus plantarum L-137 attenuates obesity and associated metabolic abnormalities in C57BL/6 J mice on a high-fat diet", BIOSCIENCE OF MICROBIOTA, FOOD AND HEALTH, vol. 40, no. 2, 1 January 2021 (2021-01-01), pages 84 - 91, XP093169305, ISSN: 2186-3342, DOI: 10.12938/bmfh.2020-040
HEBA ISMAEIL: "Ameliorative Effect of Heat-Killed Lactobacillus plantarum L.137 and/or Aloe vera against Colitis in Mice", PROCESSES, vol. 8, no. 2, CH , pages 1 - 15, XP093169313, ISSN: 2227-9717, DOI: 10.3390/pr8020225
MUROSAKI, S. YAMAMOTO, Y. ITO, K. INOKUCHI, T. KUSAKA, H. IKEDA, H. YOSHIKAI, Y.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 102, no. 1, 1 July 1998 (1998-07-01), AMSTERDAM, NL , pages 57 - 64, XP005687498, ISSN: 0091-6749, DOI: 10.1016/S0091-6749(98)70055-7
MUROSAKI S. ET AL.: "Effects of Intake of Syrup Supplemented with Nigerooligosaccharides and Heat-killed Lactobacillus plantarum L-137 on Skin Symptom and Immune Function in Patients with Atopic Dermatitis", JAPANESE PHARMACOLOGY AND THERAPEUTICS, vol. 34, no. 10, 1 January 2006 (2006-01-01), JP , pages 1087 - 1096, XP002540585, ISSN: 0386-3603
HEBA ISMAEIL: "Ameliorative Effect of Heat-Killed Lactobacillus plantarum L.137 and/or Aloe vera against Colitis in Mice", PROCESSES, vol. 8, no. 2, CH , pages 1 - 15, XP093169313, ISSN: 2227-9717, DOI: 10.3390/pr8020225
MUROSAKI, S. YAMAMOTO, Y. ITO, K. INOKUCHI, T. KUSAKA, H. IKEDA, H. YOSHIKAI, Y.: "Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 102, no. 1, 1 July 1998 (1998-07-01), AMSTERDAM, NL , pages 57 - 64, XP005687498, ISSN: 0091-6749, DOI: 10.1016/S0091-6749(98)70055-7
MUROSAKI S. ET AL.: "Effects of Intake of Syrup Supplemented with Nigerooligosaccharides and Heat-killed Lactobacillus plantarum L-137 on Skin Symptom and Immune Function in Patients with Atopic Dermatitis", JAPANESE PHARMACOLOGY AND THERAPEUTICS, vol. 34, no. 10, 1 January 2006 (2006-01-01), JP , pages 1087 - 1096, XP002540585, ISSN: 0386-3603
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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