Title:
COMPOSITION FOR LOWERING HEART RATE
Document Type and Number:
WIPO Patent Application WO/2021/117857
Kind Code:
A1
Abstract:
[Problem] To provide a composition for lowering the heart rate, the composition including lactic acid bacteria belonging to the genus Lactobacillus. [Solution] The heart rate in a subject is lowered by causing the subject to ingest a composition that includes lactic acid bacteria belonging to the genus Lactobacillus.
Inventors:
TOSHIMITSU TAKAYUKI (JP)
SASHIHARA TOSHIHIRO (JP)
ASAMI YUKIO (JP)
SASHIHARA TOSHIHIRO (JP)
ASAMI YUKIO (JP)
Application Number:
PCT/JP2020/046227
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
MEIJI CO LTD (JP)
International Classes:
A61K35/747; A23C9/123; A23L33/135; A61P9/00; A61P43/00; C12N1/20
Domestic Patent References:
| WO2004089097A1 | 2004-10-21 | |||
| WO2008120713A1 | 2008-10-09 | |||
| WO2012014971A1 | 2012-02-02 | |||
| WO2012014971A1 | 2012-02-02 |
Other References:
BELTRAN-BARRIENTOS L.M. ET AL.: "Invited review: Fermented milk as antihypertensive functional food", JOURNAL OF DAIRY SCIENCE, vol. 99, 2016, pages 4099 - 4110, XP029547669, DOI: 10.3168/jds.2015-10054
ATSUSHI HIHARA, YOICHI HAMAI, EMI, KAZUTERU TANABE, KEI UKON, KOJI OTA, KAZUHIRO YOSHIDA, YOSHIYUKI YAMAGUCHI, TETSUYA TOGE: "W-2-6 Serum sickness as an invasion indicator IL-6 Concentration and heart rate", THE JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 38, no. 7, 1 July 2005 (2005-07-01), pages 980, XP055936537, ISSN: 0386-9768, DOI: 10.5833/jjgs.38.977
TOSHIMITSU T. ET AL.: "Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial", NUTRI ENTS, vol. 12, 31 January 2020 (2020-01-31), pages 374, XP055834280
"Learning from Epidemiology: Heart Rate and Cardiovascular Disease", HEART'S SELECTION (THINKING ABOUT HEART RATE, vol. 43, 2011, pages 1397 - 1401
T. TOSHIMITSU ET AL.: "Identification of Lactobacillus plantarum strain that meliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice", J DAIRY SCI, vol. 99, 2016, pages 933 - 946, XP055469112, DOI: 10.3168/jds.2015-9916
TOHRU SAKAI ET AL.: "Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet", J NUTR SCI VITAMINOL, vol. 59, 2013, pages 144 - 147
SEINO ET AL.: "Report of the Committee on the classification and diagnostic criteria of diabetes mellitus (International Standardization Compliant Version", DIABETOLOGY, vol. 55, 2012
XU H ET AL.: "Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance", J CLIN INVEST, vol. 112, 2003, pages 1821 - 1830, XP003006859, DOI: 10.1172/JCI200319451
WEISBERG SP ET AL.: "CCR2 modulates inflammatory and metabolic effects of high-fat feeding", J CLIN INVEST, vol. 116, 2006, pages 115 - 124, XP055235118, DOI: 10.1172/JCI24335
See also references of EP 4104844A4
ATSUSHI HIHARA, YOICHI HAMAI, EMI, KAZUTERU TANABE, KEI UKON, KOJI OTA, KAZUHIRO YOSHIDA, YOSHIYUKI YAMAGUCHI, TETSUYA TOGE: "W-2-6 Serum sickness as an invasion indicator IL-6 Concentration and heart rate", THE JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 38, no. 7, 1 July 2005 (2005-07-01), pages 980, XP055936537, ISSN: 0386-9768, DOI: 10.5833/jjgs.38.977
TOSHIMITSU T. ET AL.: "Effects of 12-Week Ingestion of Yogurt Containing Lactobacillus plantarum OLL2712 on Glucose Metabolism and Chronic Inflammation in Prediabetic Adults: A Randomized Placebo-Controlled Trial", NUTRI ENTS, vol. 12, 31 January 2020 (2020-01-31), pages 374, XP055834280
"Learning from Epidemiology: Heart Rate and Cardiovascular Disease", HEART'S SELECTION (THINKING ABOUT HEART RATE, vol. 43, 2011, pages 1397 - 1401
T. TOSHIMITSU ET AL.: "Identification of Lactobacillus plantarum strain that meliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice", J DAIRY SCI, vol. 99, 2016, pages 933 - 946, XP055469112, DOI: 10.3168/jds.2015-9916
TOHRU SAKAI ET AL.: "Lactobacillus plantarum OLL2712 regulates glucose metabolism in C57BL/6 mice fed a high-fat diet", J NUTR SCI VITAMINOL, vol. 59, 2013, pages 144 - 147
SEINO ET AL.: "Report of the Committee on the classification and diagnostic criteria of diabetes mellitus (International Standardization Compliant Version", DIABETOLOGY, vol. 55, 2012
XU H ET AL.: "Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance", J CLIN INVEST, vol. 112, 2003, pages 1821 - 1830, XP003006859, DOI: 10.1172/JCI200319451
WEISBERG SP ET AL.: "CCR2 modulates inflammatory and metabolic effects of high-fat feeding", J CLIN INVEST, vol. 116, 2006, pages 115 - 124, XP055235118, DOI: 10.1172/JCI24335
See also references of EP 4104844A4
Attorney, Agent or Firm:
NAKAMURA Yukitaka et al. (JP)
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