Title:
COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC COMPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2013/100292
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diabetes or diabetic complications. More specifically, a recombinant high-density lipoprotein comprising the apolipoprotein mutant V156K in which the amino acid at position 156 of an apolipoprotein (apoA-I) is substituted with lysine, is remarkable in the inhibition of advanced glycation end-products (AGE) formation, insulin secretion and oxidative stress resistance and is excellent in the proteaction or regeneration of biological tissue so as to be effective for preventing or treating diabetes or diabetic complications, and thus would be applied to various fields as a pharmaceutical composition, a dietary supplement composition, or the like.
Inventors:
CHO KYUNG-HYUN (KR)
Application Number:
PCT/KR2012/005370
Publication Date:
July 04, 2013
Filing Date:
July 06, 2012
Export Citation:
Assignee:
UNIV YEUNGNAM IACF (KR)
CHO KYUNG-HYUN (KR)
CHO KYUNG-HYUN (KR)
International Classes:
A61K38/06; A61K38/17; A61P3/00; A61P3/10
Foreign References:
| KR100560102B1 | 2006-03-13 | |||
| KR20110039798A | 2011-04-20 | |||
| US20090131520A1 | 2009-05-21 | |||
| KR20120043583A | 2012-05-04 |
Other References:
CHO, K. H. ET AL.: "A point mutant of apolipoprotein A-I, V156K, exhibited potent anti- oxidant and anti-atherosclerotic activity in hypercholesterolemic C57BL/6 mice.", EXP. MOL. MED., vol. 39, no. 2, 30 April 2007 (2007-04-30), pages 160 - 169
CHO, K. H. ET AL.: "ApoA-I mutants V156K and R173C promote anti-inflammatory function and antioxidant activities.", EUR. J. CLIN. INVEST., vol. 36, no. 12, December 2006 (2006-12-01), pages 875 - 882
CHO, K. H.: "Enhanced delivery ofrapamycin by V156K-apoA-I high-density lipoprotein inhibits cellular proatherogenic effects and senescence and promotes tissue regeneration.", J. GERONTOL. A. BIOL. SCI. MED. SCI., vol. 66, no. 12, 28 September 2011 (2011-09-28), pages 1274 - 1285
CHO, K. H. ET AL.: "ApoA-I mutants V156K and R173C promote anti-inflammatory function and antioxidant activities.", EUR. J. CLIN. INVEST., vol. 36, no. 12, December 2006 (2006-12-01), pages 875 - 882
CHO, K. H.: "Enhanced delivery ofrapamycin by V156K-apoA-I high-density lipoprotein inhibits cellular proatherogenic effects and senescence and promotes tissue regeneration.", J. GERONTOL. A. BIOL. SCI. MED. SCI., vol. 66, no. 12, 28 September 2011 (2011-09-28), pages 1274 - 1285
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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