Title:
COMPOSITION FOR PREVENTING OR TREATING FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2021/261909
Kind Code:
A1
Abstract:
A composition according to the present invention can be used to more effectively treat or prevent the development of various fibrosis-related diseases including pulmonary fibrosis and renal fibrosis by inhibiting the activity of histone acetyltransferase (HAT).
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Inventors:
YOON HO GEUN (KR)
KIM MI JEONG (KR)
PARK SOO YEON (KR)
KIM MI JEONG (KR)
PARK SOO YEON (KR)
Application Number:
PCT/KR2021/007885
Publication Date:
December 30, 2021
Filing Date:
June 23, 2021
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/09; A23L33/10; A61P11/00; A61P43/00
Foreign References:
| KR102001437B1 | 2019-07-19 | |||
| US10405550B2 | 2019-09-10 |
Other References:
ERDTMAN H, ERIKSON, G AND NORIN, T. : "Aucuparin and methoxyaucuparin, two phenolic biphenyl derivatives from the heartwood of Sorbus aucuparia (L.", ACTA CHEMICA SCANDINAVICA., MUNKSGAARD, COPENHAGEN., DK, vol. 17, 1 January 1963 (1963-01-01), DK , XP055883219, ISSN: 0904-213X
LEE SOO YEON, KIM MI JEONG, JANG SUBHIN, LEE GYEONG-EUN, HWANG SOO-YEON, KWON YOUNGJOO, HONG JUNG YEON, SOHN MYUNG HYUN, PARK SOO-: "Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 23, no. 6, 1 June 2020 (2020-06-01), US , pages 633 - 640, XP055883224, ISSN: 1096-620X, DOI: 10.1089/jmf.2019.4670
LIN CHU-HUNG, CHANG HSUN-SHUO, LIAO CHANG-HUI, OU TAI-HSIN, CHEN IH-SHENG, TSAI IAN-LIH: "Anti-inflammatory Biphenyls and Dibenzofurans from Rhaphiolepis indica", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 73, no. 10, 22 October 2010 (2010-10-22), US , pages 1628 - 1631, XP055883280, ISSN: 0163-3864, DOI: 10.1021/np100200s
LEE SOO YEON, PARK SOO-YEON, LEE GYEONG-EUN, KIM HYUNSIK, KWON JAE-HWAN, KIM MI JEONG, YOON HO-GEUN: "Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory Activity", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 24, no. 2, 1 February 2021 (2021-02-01), US , pages 151 - 160, XP055883287, ISSN: 1096-620X, DOI: 10.1089/jmf.2020.4861
LEE SOO YEON, KIM MI JEONG, JANG SUBHIN, LEE GYEONG-EUN, HWANG SOO-YEON, KWON YOUNGJOO, HONG JUNG YEON, SOHN MYUNG HYUN, PARK SOO-: "Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 23, no. 6, 1 June 2020 (2020-06-01), US , pages 633 - 640, XP055883224, ISSN: 1096-620X, DOI: 10.1089/jmf.2019.4670
LIN CHU-HUNG, CHANG HSUN-SHUO, LIAO CHANG-HUI, OU TAI-HSIN, CHEN IH-SHENG, TSAI IAN-LIH: "Anti-inflammatory Biphenyls and Dibenzofurans from Rhaphiolepis indica", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 73, no. 10, 22 October 2010 (2010-10-22), US , pages 1628 - 1631, XP055883280, ISSN: 0163-3864, DOI: 10.1021/np100200s
LEE SOO YEON, PARK SOO-YEON, LEE GYEONG-EUN, KIM HYUNSIK, KWON JAE-HWAN, KIM MI JEONG, YOON HO-GEUN: "Aucuparin Suppresses Bleomycin-Induced Pulmonary Fibrosis Via Anti-Inflammatory Activity", JOURNAL OF MEDICINAL FOOD, MARY ANN LIEBERT, LARCHMONT, NY,, US, vol. 24, no. 2, 1 February 2021 (2021-02-01), US , pages 151 - 160, XP055883287, ISSN: 1096-620X, DOI: 10.1089/jmf.2020.4861
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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