Title:
COMPOSITION FOR PREVENTING OR TREATING KIDNEY DISEASE COMPRISING PYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/035070
Kind Code:
A1
Abstract:
The present invention provides a composition for preventing or treating kidney disease, the composition comprising a pyrazole derivative compound or a pharmaceutically acceptable salt thereof; and the composition of the present invention is effective in reducing proteinuria, reducing cell formation between glomerular blood vessels and suppressing kidney fibrosis.
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Inventors:
BAE YUN SOO (KR)
HA HUN JOO (KR)
LEE KEE IN (KR)
SONG KYUNG HEE (KR)
HA HUN JOO (KR)
LEE KEE IN (KR)
SONG KYUNG HEE (KR)
Application Number:
PCT/KR2013/006985
Publication Date:
March 06, 2014
Filing Date:
August 02, 2013
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61K31/4155; A61K31/41; A61P13/12
Foreign References:
| KR20110025149A | 2011-03-09 | |||
| KR20040094464A | 2004-11-10 | |||
| US5292744A | 1994-03-08 | |||
| EP2050745A1 | 2009-04-22 | |||
| KR100942382B1 | 2010-02-12 | |||
| KR20110025149A | 2011-03-09 | |||
| KR20110025151A | 2011-03-09 |
Other References:
ALMANSA, C. ET AL.: "Synthesis and structure-activity relationship of a new series of potent AT selective angiotensin II receptor antagonists: 5-(biphenyl-4-ylmethyl)pyrazoles", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, 1997, pages 547 - 558, XP000652306
SAWYER, J. S. ET AL.: "Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 19, 2003, pages 3953 - 3956, XP002265227
SCHIEPPATI A; REMUZZI G: "Chronic renal diseases as a public health problem: epidemiology, social, and economic implications", KIDNEY INT, vol. 98, no. 1, 2005, pages S7 - S10
QIAN Y; FELDMAN E; PENNATHUR S; KRETZLER M; BROSIUS FC 3RD: "From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy", DIABETES, vol. 57, 2008, pages 1439 - 45
"Atlas of End-Stage Renal Disease in the United States", 2011, NATIONAL INSTITUTES OF HEALTH
ZHANG MZ; WANG S; YANG S; YANG H; FAN X; TAKAHASHI T; HARRIS RC: "The Role of Blood Pressure and the Renin-Angiotensin System in Development of Diabetic Nephropathy (DN) in eNOS-/- db/db Mice", AM J PHYSIOL RENAL PHYSIOL., 2011
HWANG I; LEE J; PARK J; HUH JY; LEE HB; HO YS; HA H: "Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction", DIABETES, vol. 72, 2012, pages 8 - 738
LEE EA; SEO JY; JIANG Z; YU MR; KWON MK; HA H; LEE HB: "Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney", KIDNEY INT., vol. 67, 2005, pages 1762 - 71
NOH H; KIM JS; HAN K-H; LEE GT; SONG JS; CHUNG SH; JEON JS; HA H; LEE HB: "Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane", KIDNEY INT., vol. 69, 2006, pages 2022 - 2028, XP008162013, DOI: doi:10.1038/sj.ki.5001506
SAWYER, J. S. ET AL.: "Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 19, 2003, pages 3953 - 3956, XP002265227
SCHIEPPATI A; REMUZZI G: "Chronic renal diseases as a public health problem: epidemiology, social, and economic implications", KIDNEY INT, vol. 98, no. 1, 2005, pages S7 - S10
QIAN Y; FELDMAN E; PENNATHUR S; KRETZLER M; BROSIUS FC 3RD: "From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy", DIABETES, vol. 57, 2008, pages 1439 - 45
"Atlas of End-Stage Renal Disease in the United States", 2011, NATIONAL INSTITUTES OF HEALTH
ZHANG MZ; WANG S; YANG S; YANG H; FAN X; TAKAHASHI T; HARRIS RC: "The Role of Blood Pressure and the Renin-Angiotensin System in Development of Diabetic Nephropathy (DN) in eNOS-/- db/db Mice", AM J PHYSIOL RENAL PHYSIOL., 2011
HWANG I; LEE J; PARK J; HUH JY; LEE HB; HO YS; HA H: "Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction", DIABETES, vol. 72, 2012, pages 8 - 738
LEE EA; SEO JY; JIANG Z; YU MR; KWON MK; HA H; LEE HB: "Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney", KIDNEY INT., vol. 67, 2005, pages 1762 - 71
NOH H; KIM JS; HAN K-H; LEE GT; SONG JS; CHUNG SH; JEON JS; HA H; LEE HB: "Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane", KIDNEY INT., vol. 69, 2006, pages 2022 - 2028, XP008162013, DOI: doi:10.1038/sj.ki.5001506
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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