Title:
COMPOSITION FOR PREVENTING OR TREATING VASCULAR OR CARDIAC VALVULAR CALCIFICATION, CONTAINING THIAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/032426
Kind Code:
A1
Abstract:
The present invention relates to: a pharmaceutical composition for preventing or treating vascular or cardiac valvular calcification, containing a thiamine derivative and a pharmaceutically acceptable salt thereof; and a food composition for alleviating vascular or cardiac valvular calcification, containing a thiamine derivative and a salt thereof, and the compositions of the present invention can be effectively used for a use of preventing, treating or alleviating vascular or cardiac valvular calcification.
Inventors:
LEE IN KYU (KR)
JEON JAE HAN (KR)
OH CHANG JOO (KR)
LEE JI MIN (KR)
JEON JAE HAN (KR)
OH CHANG JOO (KR)
LEE JI MIN (KR)
Application Number:
PCT/KR2019/009015
Publication Date:
February 13, 2020
Filing Date:
July 22, 2019
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K31/505; A23L33/10; A61P9/00
Foreign References:
| EP0820770A2 | 1998-01-28 | |||
| KR20180092019A | 2018-08-17 | |||
| KR20190087554A | 2019-07-24 |
Other References:
RAJ V; OJHA; S; HOWARTH F C; BELUR; P D; SUBRAMANYA S B: "Therapeutic potential of benfotiamine and its molecular targets", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, vol. 22, no. 10, 1 January 2018 (2018-01-01), pages 3261 - 3273, XP055685953, DOI: 10.26355/eurrev_201805_15089
EUGENE J BARRETT; LIU ZHENQI; KHAMAISI MOGHER; KING GEORGE L; KLEIN RONALD; KLEIN BARBARA E K; HUGHES TIMOTHY M; CRAFT SUZANNE; FR: "Diabetic Microvascular Disease: An Endocrine Society Scientific Statement", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 102, no. 12, 1 December 2017 (2017-12-01), pages 4343 - 4410, XP055685993, ISSN: 0021-972X, DOI: 10.1210/jc.2017-01922
EUN-BANG LEE; LEE YOUNG SOON; KIM OK KYUNG: "The Preventive Effect of Fursulthiamine on Dietary Hypertension in Rats", FURSULTHIAMINE, vol. 43, no. 1, 1 January 1999 (1999-01-01), pages 91 - 97, XP055686001
NICOLL RACHEL, HOWARD JOHN MCLAREN, HENEIN MICHAEL Y: "Cardiovascular Calcification and Bone: A Comparison of the Effects of Homocysteine and Dietary and Serum B Vitamins", ANNALS OF VASCULAR MEDICINE & RESEARCH, vol. 4, no. 4, 1065, 27 July 2017 (2017-07-27), pages 1 - 10, XP055778145, ISSN: 2378-9344
See also references of EP 3834828A4
EUGENE J BARRETT; LIU ZHENQI; KHAMAISI MOGHER; KING GEORGE L; KLEIN RONALD; KLEIN BARBARA E K; HUGHES TIMOTHY M; CRAFT SUZANNE; FR: "Diabetic Microvascular Disease: An Endocrine Society Scientific Statement", THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 102, no. 12, 1 December 2017 (2017-12-01), pages 4343 - 4410, XP055685993, ISSN: 0021-972X, DOI: 10.1210/jc.2017-01922
EUN-BANG LEE; LEE YOUNG SOON; KIM OK KYUNG: "The Preventive Effect of Fursulthiamine on Dietary Hypertension in Rats", FURSULTHIAMINE, vol. 43, no. 1, 1 January 1999 (1999-01-01), pages 91 - 97, XP055686001
NICOLL RACHEL, HOWARD JOHN MCLAREN, HENEIN MICHAEL Y: "Cardiovascular Calcification and Bone: A Comparison of the Effects of Homocysteine and Dietary and Serum B Vitamins", ANNALS OF VASCULAR MEDICINE & RESEARCH, vol. 4, no. 4, 1065, 27 July 2017 (2017-07-27), pages 1 - 10, XP055778145, ISSN: 2378-9344
See also references of EP 3834828A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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