Title:
COMPOSITIONS, METHODS, AND ASSOCIATED DEVICES FOR CRYOPRESERVATION OF BIOLOGICAL SPECIMENS
Document Type and Number:
WIPO Patent Application WO/2024/015037
Kind Code:
A3
Abstract:
The present invention relates to the compositions, methods, and associated devices (1) for the cryopreservation of biological specimens that enables to freeze and thaw the entire specimen by straightforwardly protecting its three-dimensional architecture. The invention comprises compositions including reagents to protect the specimen and preserve the physiological conditions. The methods comprise fewer steps excluding the need for other solutions used in conventional methods. The methods also eliminate stressful steps for biological specimens in conventional methods including harvesting, pipetting, centrifuging, and transferring. With this invention, the entire content of the specimen can be frozen, stored long-term in a single cell culture vessel with one of the associated devices (1) described here, and then thawed while still in the device (1). The biological specimens frozen by that method render high post-thawing viability. Moreover, the invention reduces cryoprotectant-related toxic events, human errors, and contamination risk.
Inventors:
AKTAŞ RANAN GÜLHAN (TR)
Application Number:
PCT/TR2023/050674
Publication Date:
February 22, 2024
Filing Date:
July 11, 2023
Export Citation:
Assignee:
AKTAS RANAN GUELHAN (TR)
International Classes:
A01N1/02; C12N1/04; C12N5/00
Foreign References:
| CN112335648A | 2021-02-09 | |||
| EP3576527A1 | 2019-12-11 |
Other References:
WHALEY DAVID, DAMYAR KIMIA, WITEK RAFAL P., MENDOZA ALAN, ALEXANDER MICHAEL, LAKEY JONATHAN RT: "Cryopreservation: An Overview of Principles and Cell-Specific Considerations", CELL TRANSPLANTATION, vol. 30, 1 January 2021 (2021-01-01), US , pages 1 - 12, XP093145316, ISSN: 0963-6897, DOI: 10.1177/0963689721999617
Attorney, Agent or Firm:
DESTEK PATENT, INC. (TR)
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