Title:
COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING CIRCULATING TUMOR CELLS CTCS
Document Type and Number:
WIPO Patent Application WO/2012/003287
Kind Code:
A3
Abstract:
The present invention relates to the field of virology. More specifically, the present invention relates to the use of viral constructs to detect and quantify circulating tumor cells. In one embodiment, the present invention provides an adenovirus construct comprising (a) a cell type specific promoter that drives adenoviral replication; and (b) at least one reporter gene incorporated into the viral Major Late Transcriptional Unit. In another embodiment, an adenovirus construct comprises (a) prostate selective probasin promoter operably linked to the E1 gene; and (b) prostate specific antigen enhancer operably linked to the probasin promoter.
Inventors:
CHOWDHURY WASIM HAIDER (US)
WU PING (US)
RODRIGUEZ RONALD (US)
WU PING (US)
RODRIGUEZ RONALD (US)
Application Number:
PCT/US2011/042547
Publication Date:
August 02, 2012
Filing Date:
June 30, 2011
Export Citation:
Assignee:
UNIV JOHNS HOPKINS (US)
LUPOLD SHAWN EDWARD (US)
CHOWDHURY WASIM HAIDER (US)
WU PING (US)
RODRIGUEZ RONALD (US)
LUPOLD SHAWN EDWARD (US)
CHOWDHURY WASIM HAIDER (US)
WU PING (US)
RODRIGUEZ RONALD (US)
International Classes:
C12N15/861; A61K48/00; A61P35/00; C12Q1/68
Foreign References:
| US20020136707A1 | 2002-09-26 | |||
| US7482156B2 | 2009-01-27 | |||
| US20040126785A1 | 2004-07-01 |
Other References:
YING LI ET AL.: "Prostate-specific Expression of the Diphtheria Toxin A Chain (DT-A): Studies of Inducibility and Specificity of Expression of Prostate- specific Antigen Promoter-driven DT-A Adenoviral-mediated Gene Transfer.", CANCER RESEARCH., vol. 62, no. 9, 2002, pages 2576 - 2582, XP002993226
MICHAEL BERG ET AL.: "Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit.", PNAS., vol. 102, no. 12, 2005, pages 4590 - 4595
MICHAEL BERG ET AL.: "Viable adenovirus vaccine prototypes: High-level production of a papillomavirus capsid antigen from the major late transcriptional unit.", PNAS., vol. 102, no. 12, 2005, pages 4590 - 4595
Attorney, Agent or Firm:
GALVEZ, Guido J. (5th FloorBaltimore, Maryland, US)
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