Title:
COMPOSITIONS AND METHODS FOR PREVENTING OR REDUCING INFLAMMATION BY INHIBITING CASPASE-9
Document Type and Number:
WIPO Patent Application WO/2020/223212
Kind Code:
A3
Abstract:
The present disclosure relates to a method of preventing or decreasing inflammation in a patient comprising administering to the patient in need thereof an effective amount of a caspase-9 signaling pathway inhibitor. The caspase-9 signaling pathway inhibitor may include a peptide caspase-9 inhibitor and/or may be conjugated to a cell-penetrating peptide. The present disclosure further includes pharmaceutical compositions including a caspase-9 signaling pathway inhibitor. The disclosure further relates to the use of such compositions in a method of treating inflammation of the retina associated with retinal vein occlusion, diabetic macular edema, retinal detachment, ocular trauma, retinitis pigmentosa, age-related macular degeneration, uveitis, a retinal degenerative disease, glaucoma, Multiple sclerosis, Behcets, Lupus, Systemic sarcoidosis, Central serous chorioretinopathy, Leber's Hereditary Optic Neuropathy, Leigh Syndrome, Stargardt, retinitis pigmentosa, Best disease, or birdshot retinopathy.
Inventors:
TROY CAROL (US)
AVRUTSKY MARIA (US)
AVRUTSKY MARIA (US)
Application Number:
PCT/US2020/030228
Publication Date:
December 10, 2020
Filing Date:
April 28, 2020
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
A61K47/64; A61K38/55; A61P9/10; A61P27/02
Domestic Patent References:
| WO2018013519A1 | 2018-01-18 | |||
| WO2001039792A2 | 2001-06-07 |
Attorney, Agent or Firm:
RAGUSA, Paul, A. et al. (US)
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